펩스타틴 A

한글명:펩스타틴 A

카스 번호26305-03-3

상품명:Pepstatin

CBNumberCB5155004

분자식C34H63N5O9

포뮬러 무게685.89

MOL 파일26305-03-3.mol

동의어(한글)

펩스타틴A

펩스타틴A(PEPSTATINA)

화학적 성질

녹는점	233 °C (dec.)(lit.)
알파	D27 -90.3° (c = 0.288 in methanol)
끓는 점	695.91°C (rough estimate)
밀도	1.1340 (rough estimate)
굴절률	1.7500 (estimate)
저장 조건	2-8°C
용해도	메탄올 중 10% 아세트산: 1 mg/mL
산도 계수 (pKa)	4.17±0.10(Predicted)
물리적 상태	흰색 고체
색상	무색 바늘
optical activity	Optical rotation: -90.0 ± 5° (c = 0.5, MeOH, 20°C).
수용성	이는 메탄올(9:1 메탄올:아세트산)(1 mg/ml), 에탄올(1-2 mg/ml, 최대 60°C의 열) 중 10%(v/v) 아세트산, DMSO( 5mg/ml), 메탄올(1mg/ml) 및 아세트산. 벤젠, 클로로포름, 물, 1M NaOH 및 에테르에 용해되지 않습니다.
BRN	2201362
안정성	안정적인. 강염기, 강산과 호환되지 않습니다.
InChIKey	JKGWASGTXVCDML-LXTPJMTPSA-N
CAS 데이터베이스	26305-03-3(CAS DataBase Reference)

위험 및 안전 성명

안전지침서	22-24/25
WGK 독일	2
RTECS 번호	SC6155000
F 고인화성물질	10
HS 번호	29241990
독성	LD50 in mice, rats, rabbits, dogs (mg/kg): 1090, 875, 820, 450 i.p.; all >2000 orally (Umezawa, 1970)

그림문자(GHS)

펩스타틴 A MSDS

펩스타틴 A 화학적 특성, 용도, 생산

개요
Pepstatin A is a bacterial-derived chemotactic pentapeptide that irreversibly inhibits aspartic proteases, including pepsin, gastricsin, renin, cathepsin E, and cathepsin D. Pepstatin A has been reported to stimulate human neutrophil degranulation (EC₅₀ = 0.75 μM) and super oxide production (EC₅₀ = 1.5 μM). Pepstatin A has been widely used as a research tool in studies of protease mechanisms and biological functions and has been examined as a therapeutic agent for inflammatory conditions including gastric ulcer, edema, and hypertension.
화학적 성질
solid
용도
Pepstatin A are natural, statine-containing peptides that acts as inhibitor of aspartic protease enzymes.
일반 설명
Pepstatin A is a naturally occurring chemotactic peptide and inhibitor of aspartic proteases that was initially isolated from culture filtrates of various Actinomycetes species, with the initial name simply of “pepstatin”. This name was later modified to “pepstatin A” to distinguish the original pepstatin from later derivatives. Pepstatin A notably contains the unusual amino acid 4-amino-hydroxy-6-methylheptanoic acid (AHMHA), which is known also as statine. The amino acid sequence of pepstatin A is N-Isovaleryl-L-Valyl-L-Valyl-AHMHA-L-Alanyl-AHMHA.
Safety Profile
Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
효소 저해제
This naturally occurring statine-containing peptidomimetic (FWfree-acid = 685.90 g/mol; CAS 26305-03-3), also called pepstatin A and isovalerylpepstatin and named systematically as N-(isovaleryl)-L-valyl-L-valyl-statylL-alanyl-statine (where the statyl residue is a (3S,4S)-4-amino-3-hydroxy-6- methylheptanoyl residue and the C-terminal statine is the corresponding acid), is a presumptive transition-state analogue for prototypical aspartate proteinase pepsin (Ki = 46 pM). Pepstatin will also inhibit other carboxy proteinases. The inhibitory effectiveness of statine-containing peptides has been widely exploited by incorporating the statine residue into peptides that otherwise match sequence preferences of the target enzyme’s sub-sites. Because pepstatin has a low solubility in water, it is often dissolved indimethyl sulfoxide, methanol, or ethanol. Note that many derivatives of pepstatin are available, each displaying a different spectrum of inhibitory effects. Pepstatin B and C are the N-(n-caproyl)- and N-(iso-caproyl)- derivatives, respectively. Note: Above a critical concentration of 0.1 mM in low ionic-strength and neutral buffers, pepstatin often polymerizes into filaments that be several micrometers in length and have characteristic diameters ranging between 6 and 12 nm

펩스타틴 A 준비 용품 및 원자재

펩스타틴 A 공급 업체

펩스타틴 A 관련 검색

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