세틸 알코올

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P304+P340：흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

  P405：밀봉하여 저장하시오.

세틸 알코올 화학적 특성, 용도, 생산

• 개요

  1-Hexadecanol is a waxy white powder or flake form at room temperature, and is insoluble in water and soluble in alcohols and oils. Discovered by Chevrenl in 1913, It is one of the oldest known long-chain alcohol. It can be produced from the reduction of palmitic acid. 1-Hexadecanol may be contained in cosmetic and personal care products such as shampoos, creams and lotions. it is mainly used as an opacifier, emulsifier, and thickening agent that alter the thickness of the liquid, and increase and stabilize the foaming capacity.

• 화학적 성질

  Cetyl alcohol occurs as waxy, white flakes, granules, cubes, or castings. It has a faint characteristic odor and bland taste.

• 출처

  Reported as a major constituent of spermaceti oil, where it is present chiefy as cetyl palmitate Also reported found in guava, peach, pear, kohlrabi, baked potato, mustard, Parmesan cheese, butter, milk powder, boiled egg, cooked chicken, roasted beef, beef fat, whiskies, tea, starfruit, mango, rice, licorice, kiwifruit, loquat, endive, shrimp, crab, clam, Cape gooseberry and pawpaw

• 용도

  1-Hexadecanol has been used in preparation of:
  (±)-2-methoxyheptadecanoic acid (fatty acid)
  high-chain fatty acid esters of 1-hexadecanol, novel organic phase change material for thermal energy storage
  hexadecane (alkane) in the presence of membrane fraction of Vibrio furnissii M1

• 생산 방법

  Cetyl alcohol may be manufactured by a number of methods such as esterification and hydrogenolysis of fatty acids or by catalytic hydrogenation of the triglycerides obtained from coconut oil or tallow. Cetyl alcohol may be purified by crystallization and distillation.

• 정의

  ChEBI: 1-Hexadecanol is a long chain fatty alcohol that is hexadecane substituted by a hydroxy group at position 1. It is a synthetic, solid, fatty alcohol and nonionic surfactant. It is used as an emulsifying agent in pharmaceutical preparations.

• 일반 설명

  1-Hexadecanol is a free fatty acid alcohol generally used as an emulsifier, emollient, opacifier and surfactant in cosmetics formulations.

• Safety

  Cetyl alcohol is mainly used in topical formulations, although it has also been used in oral and rectal preparations.
  Cetyl alcohol has been associated with allergic delayed-type hypersensitivity reactions in patients with stasis dermatitis. Crosssensitization with cetostearyl alcohol, lanolin, and stearyl alcohol has also been reported. It has been suggested that hypersensitivity may be caused by impurities in commercial grades of cetyl alcohol since highly refined cetyl alcohol (99.5%) has not been associated with hypersensitivity reactions.
  LD₅₀ (mouse, IP): 1.6 g/kg
  LD₅₀ (mouse, oral): 3.2 g/kg
  LD₅₀ (rat, IP): 1.6 g/kg
  LD₅₀ (rat, oral): 5 g/kg

• 저장

  Cetyl alcohol is stable in the presence of acids, alkalis, light, and air; it does not become rancid. It should be stored in a well-closed container in a cool, dry place.

• Purification Methods

  Crystallise the alcohol from aqueous EtOH or from cyclohexane. Alternatively purify it by zone refining. The purity can be checked by gas chromatography. [Beilstein 1 H 429, 1 I 219, 1 II 466, 1 III 1815, 1 IV 1876.]

• 비 호환성

  Incompatible with strong oxidizing agents. Cetyl alcohol is responsible for lowering the melting point of ibuprofen, which results in sticking tendencies during the process of film coating ibuprofen crystals.

• Regulatory Status

  Included in the FDA Inactive Ingredients Database (ophthalmic preparations, oral capsules and tablets, otic and rectal preparations, topical aerosols, creams, emulsions, ointments and solutions, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

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