메틸렌 블루, 트리수화물

한글명:메틸렌 블루, 트리수화물

카스 번호7220-79-3

상품명:Methylene Blue trihydrate

CBNumberCB3748860

분자식C16H20ClN3OS

포뮬러 무게337.87

MOL 파일7220-79-3.mol

동의어(한글)

3,7-비스(디메틸아미노)페노티아진-5-ISM염화물,트리수화물

C.I.베이직블루9트리수화물

메틸렌블루,트리수화물

화학적 성질

녹는점	190 °C (dec.)(lit.)
밀도	0.98 g/mL at 25 °C
인화점	14 °C
저장 조건	no restrictions.
용해도	물에 용해됨, 클로로포름; 에탄올에 거의 용해되지 않음
색상 색인 번호	52015
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	2.6, 11.2(at 25℃)
색상	녹색
수용성	4g/100mL
최대 파장(λmax)	668 nm, 609 nm
Merck	13,6085
안정성	안정적인. 염기, 환원제, 강산화제와 호환되지 않습니다.
생물학 분야의 응용	Diagnosis of tauopathy,Alzheimer’s disease (AD),Pick’s disease; treating prophylaxis; dental materials
InChIKey	YAFGUSOAMIMROI-UHFFFAOYSA-M
CAS 데이터베이스	7220-79-3(CAS DataBase Reference)
IARC	3 (Vol. 108) 2016
EPA	Methylene blue trihydrate (7220-79-3)

위험 및 안전 성명

위험품 표기	Xn,F
위험 카페고리 넘버	22-36/37/38-11
안전지침서	26-36-24/25-16-7
유엔번호(UN No.)	UN 1170 3/PG 2
WGK 독일	3
RTECS 번호	SP5740000
TSCA	Yes
HS 번호	32129000

그림문자(GHS)

메틸렌 블루, 트리수화물 MSDS

메틸렌 블루, 트리수화물 화학적 특성, 용도, 생산

화학적 성질
Methylene Blue trihydrate is a dark green crystalline powder that has a bronze-like luster. When dissolved in water or alcohol, it creates a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It can also inhibit guanylate cyclase and has been used to treat cyanide poisoning and lower levels of methemoglobin.
용도
Methylene Blue trihydrate finds many uses in biology and chemistry. It acts as a GCS inhibitor, biological stain and redox indicator. It inhibits tau filament formation. Further, it is reported to bind to the M2 subtype of muscarinic receptors in rat cardiac myocytes and thus exhibit antimuscarinic effects on IK, ACh and ICa. It also inhibits endothelium-dependent relaxation of isolated blood vessels.
제조 방법
Methylene blue is synthesized commercially by oxidation of N,N-dimethyl-phenylenediamine with sodium dichromate (Na2Cr2O7) in the presence of sodium thiosulfate (Na2S2O3), followed by further oxidation in the presence of N,N-dimethylaniline (NTP, 2008). Methylene blue hydrochloride is isolated by addition of 30% hydrochloric acid and of a saturated common salt solution to the dye solution; after filtration, the product is washed with a 2% common salt solution. Instead of sodium dichromate, manganese dioxide, and catalytic amounts of copper sulfate can be used for the oxidation (Berneth, 2008).
Methylene blue of high purity can be obtained by chloroform extraction of impurities from solutions of raw dye in borate buffer at pH 9.5–10, followed by acidification of the aqueous solution and isolation of the dye (Berneth, 2008).
IARC Monographs
일반 설명
Methylene blue trihydrate appears as odorless or almost odorless dark green crystals with bronze luster or dark green crystalline powder. pH (1% solution in water) 3 to 4.5. (NTP, 1992)
공기와 물의 반응
Hygroscopic. Water soluble. Gives a blue solution in water.
반응 프로필
Methylene Blue trihydrate is incompatible with strong oxidizing agents, caustics, alkali metal iodides and reducing agents. Also incompatible with dichromates. Methylene Blue trihydrate forms double salts with many inorganic salts. Is bleached reversibly by (zinc + hydrochloric acid) or sodium hydrosulfite. In aqueous solution, Methylene Blue trihydrate is decolorized by zinc dust and dilute sulfuric acid, but the color is restored upon exposure to air and more rapidly upon addition of ammonium hydroxide.
화재위험
Flash point data for Methylene Blue trihydrate are not available; however, Methylene Blue trihydrate is probably combustible.

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