판토텐산칼슘

한글명:판토텐산칼슘

카스 번호137-08-6

상품명:Calcium D-Pantothenate

CBNumberCB3695335

분자식C9H17NO5.1/2Ca

포뮬러 무게476.53

MOL 파일137-08-6.mol

동의어(한글)

(+)-판토텐산칼슘염

(R)-N-(2,4-디히드록시-3,3-디메틸-1-옥소부틸)-베타-알라닌,칼슘염(2:1)((R)-N-

D-판토텐산,칼슘염

화학적 성질

녹는점	190 °C
알파	26.5 º (c=5, in water)
굴절률	27 ° (C=5, H2O)
인화점	145 °C
저장 조건	2-8°C
용해도	H₂O: 50 mg/mL at 25°C, 투명, 거의 무색
물리적 상태	가루
색상	흰색 또는 거의 흰색
수소이온지수(pH)	6.8-7.2 (25℃, 50mg/mL in H2O)
냄새	냄새 없는
optical activity	[α]20/D +27±2°, c = 5% in H2O
수용성	물에 용해됩니다.
감도	Hygroscopic
Merck	14,7015
BRN	3769272
안정성	안정적이지만 습기나 공기에 민감할 수 있습니다. 강산, 강염기와 호환되지 않습니다.
InChIKey	FAPWYRCQGJNNSJ-UBKPKTQASA-L
LogP	-0.849 (est)
CAS 데이터베이스	137-08-6(CAS DataBase Reference)
EPA	Calcium pantothenate (137-08-6)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

20/21/22-37/38-41-48

안전지침서

24/25-45-36/37/39-26-22

WGK 독일

RTECS 번호

RU4375000

F 고인화성물질

3-10

TSCA

Yes

HS 번호

29362400

NFPA 704:

	0
0		0

그림문자(GHS)

판토텐산칼슘 MSDS

판토텐산칼슘 화학적 특성, 용도, 생산

순도시험

(1) 액성 : 이 품목의 수용액(2→10)의 pH는 7.0～9.0이다.
  (2) 비선광도 : 이 품목은 105℃에서 3시간 건조한 다음, 약 1.25g을 정밀히 달아 물에 녹여 25mL로 하고 이 액의 선광도를 측정할 때, ＝+25～+28.5°이어야한다.
  (3) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.
  (4) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.
  (5) 알칼로이드 : 이 품목 50mg에 물 5mL를 가해 녹이고 몰리브덴산암모늄시액 0.5mL 및 인산(1→10) 5mL를 가할 때, 탁해져서는 아니 된다.
확인시험

(1) 이 품목 50mg을 수산화나트륨시액 5mL에 녹이고 황산동시액 1방울을 가하면 청자색을 낸다.
(2) 이 품목 50mg에 수산화나트륨시액 5mL를 가하여 1분간 끓여 식힌 다음 묽은염산 2mL 및 염화제이철시액 2방울을 가할 때, 진한 황색을 나타낸다.
(3) 이 품목의 수용액(1→20)은 확인시험법 중 칼슘염의 반응을 나타낸다.
정량법

(1) 질소 : 이 품목을 건조한 다음 약 50mg을 정밀히 달아 질소정량법에 따라 질소를 정량한다.
(2) 칼슘 : 이 품목을 건조한 다음 약 0.5g을 정밀히 달아 물 80mL를 가하여 녹이고 0.05M 이.디.티.에이.용액 15mL를 정확히 가하고 다시 수산화나트륨용액(1→10) 15mL 및 2-옥시-1-(2''-옥시-4''-설포-1''-나프틸아조)-3-나프토에산시약 약 0.1g을 가하고 계속해서 0.05M 이.디.티.에이.용액으로 적정한다. 종말점은 적색이 완전히 소실되어 청색으로 변하는 점이다.
0.05M 이.디.티.에이.용액 1mL ＝ 2.004mg Ca
화학적 성질
Calcium D-Pantothenate is white crystalline powder
역사
Pantothenic acid (PA), also known as vitamin B5, is essential to all forms of life. Its name is derived from the Greek word pantos that means “everywhere”, which is appropriate for this widely, distributed vitamin.
용도
D-(+)-Pantothenic acid calcium salt is a member of the B complex vitamins; essential vitamin for the biosynthesis of coenzyme A in mammalian cells. Occurs ubiquitously in all animal and plant tissue. The richest common source is liver, but jelly of the queen bee contains 6 times as much as liver. Rice bran and molasses are other good sources.
정의
Calcium pantothenate, also known as calcium D-pantothenate or calcium pantothenic acid, is a naturally occurring form of pantothenic acid, an essential vitamin found in various foods. Calcium pantothenate is generally recognized as safe (GRAS) in the United States and in Europe. The US FDA requires infant formulas have at least 300 micrograms (mcg) per 100 calories of prepared formula.
화학 반응
Pantothenic acid is a constituent of coenzyme A, which participates in numerous enzyme reactions. CoA was discovered as an essential cofactor for the acetylation of sulfanilamide in the liver and of choline in the brain.
Biological Functions
Calcium D-Pantothenate accelerates the wound healing process by increasing the number of migrating cells, their distance and hence their speed. In addition, cell division is increased and the protein synthesis changed. Hence, higher quantities of pantothenate are locally required to enhance wound healing.
일반 설명
The first suggestion for the existance of vitamin B₅ came from Carter et al. in 1930; although it was never characterized or isolated. This vitamin is synthesized by most green plants and microorganisms. Excellent sources of the vitamin are liver, egg yolk, whole grains, and fortified ready-to-eat cereals. However, as the original name implies, many foods contain sufficient pantothenic acid to supply dietary needs.
Chemically, pantothenic acid is considered to be aβ-alanine derivative of the asymmetric pantoic acid and thus shows asymmetry. Only the naturally occurring D(+)- stereoisomer (with R configuration) is biologically active and the L(-)-stereoisomer (with S configuration) is inactive. When its carboxylate functional group is attached through an amide linkage with β-mercaptoethylamine, it is known as pantetheine (also spelled pantotheine). The biologically active form of pantothenic acid, CoA, is formed when the terminal alcoholic function of pantetheine is attached to ADP 3'-phosphate.
Clinical Use
The only therapeutic indication for pantothenic acid is intreatment of a known or suspected deficiency of this vitamin.Because of the ubiquitous nature of pantothenic acid, deficiencystates of this vitamin are only seen experimentally byuse of synthetic diets devoid of the vitamin, by use of thevitamin antagonist, ω-methylpantothenic, or both. In a 1991review, Tahiliani and Beinlich described that the mostcommon symptoms associated with pantothenic acid deficiencywere headache, fatigue, and a sensation of weakness.Sleep disturbances and gastrointestinal disturbances, amongothers, were also noted. The most likely setting for pantothenicacid deficiency is in the setting of alcoholism wherea multiple vitamin deficiency exists confounding the exactrole of the pantothenic acid deficiency as compared to theother vitamins. Because a deficiency of a single B vitamin israre, pantothenic acid is commonly formulated in multivitaminor B-complex preparations.
Safety Profile
Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. A vitamin. See also CALCIUM COMPOUNDS. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
The salt crystallises as needles from MeOH, EtOH or isoPrOH (with 0.5mol of isoPrOH). It is moderately hygroscopic. The S-benzylisothiuronium salt has m 151-152o (149o when crystallised from Me2CO). [Kagan et al. J Am Chem Soc 79 3545 1957, Wilson et al. J Am Chem Soc 76 5177 1954, Stiller & Wiley J Am Chem Soc 63 1239 1941, Beilstein 4 IV 2569.]

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