R모다피닐

한글명:R모다피닐

카스 번호112111-43-0

상품명:Armodafinil

CBNumberCB3500844

분자식C15H15NO2S

포뮬러 무게273.35

MOL 파일112111-43-0.mol

동의어(한글)

R모다피닐

화학적 성질

녹는점	156-1580C
끓는 점	559.1±50.0 °C(Predicted)
밀도	1.283
저장 조건	Controlled Substance, -20°C Freezer
용해도	DMSO: ≥16mg/mL
산도 계수 (pKa)	14.88±0.40(Predicted)
물리적 상태	가루
색상	흰색에서 황갈색까지
optical activity	[α]/D -15 to -20° in methanol (C=1)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

안전지침서

26-39

WGK 독일

NFPA 704:

	0
3		0

그림문자(GHS)

R모다피닐 화학적 특성, 용도, 생산

개요
Armodafinil, an α1-adrenoceptor agonist, was launched for the oral treatment of excessive sleepiness associated with narcolepsy, SWSD, and obstructive sleep apnea/hypopnea syndrome (OSA). It is the R-enantiomer of modafinil, which is a previously marketed wake-promoting agent. The key differentiator for armodafinil is its longer pharmacokinetic half-life as compared with the S-enantiomer (10-14 hvs.3-4h). At therapeutic concentrations, armodafinil does not bind to most of the potentially relevant receptors for sleep/wake regulation (e.g., serotonin, dopamine, and adenosine receptors) or transporters of neurotransmitters or enzymes involved in sleep/wake regulation (e.g., serotonin, norepinephrine, and phosphodiesterase VI transporters). Both armodafinil and modafinil block dopamine reuptake by binding to the dopamine transporter and increasing dopamine concentrations in certain regions of the brain. However, dopamine receptor antagonists (e.g., haloperidol) and dopamine synthesis inhibitors (e.g., α-methyl-p-tyrosine) do not block modafinil’s action.
In addition to its wake-promoting effects and ability to increase locomotor activity in animals, modafinil produces psychoactive and euphoric effects, alterations in mood, perception, thinking, and feelings typical of other CNS stimulants in humans. Modafinil was also partially discriminated as stimulant-like. However, the potential for abuse and dependency appears to be lower for modafinil than amphetamine-like stimulants.The most common adverse events associated with armodafinil included headache, nausea, dizziness, and insomnia.
화학적 성질
White Solid
용도
Used for treatment of excessive sleepiness, a1-adrenoceptor agonist
정의
ChEBI: A 2-[(diphenylmethyl)sulfinyl]acetamide that has R configuration at the sulfur atom. Like its racemate, modafinil, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disord r. Peak concentration in the blood later occurs later following administration than with modafinil, so it is thought that armodafinil may be more effective than modafinil in treating people with excessive daytime sleepiness.

Send Inquriy