우라실 겨자

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H300：삼키면 치명적임

  H315：피부에 자극을 일으킴

  H318：눈에 심한 손상을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

  H351：암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재)

• 예방조치문구

  P201：사용 전 취급 설명서를 확보하시오.

  P202：모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P270：이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P281：요구되는 개인 보호구를 착용하시오

  P301+P310：삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

  P308+P313：노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.

  P310：즉시 의료기관(의사)의 진찰을 받으시오. 삼켰다면 즉시 의료기관(의사)의 도움을 받으시오.

  P321：(…) 처치를 하시오.

  P330：입을 씻어내시오.

  P332+P313：피부 자극이 생기면 의학적인 조치· 조언을 구하시오.

  P362：오염된 의복을 벗고 세척 후에 재사용하기

  P405：밀봉하여 저장하시오.

  P501：...에 내용물 / 용기를 폐기 하시오.

우라실 겨자 화학적 특성, 용도, 생산

• 개요

  Uracil mustard appears as creamy/off-white, odourless, crystalline powder. It is used as an anti-cancer medicine. Uracil mustard is a chemotherapy drug that belongs to the class of alkylating agents. It is used for its anti-neoplastic properties. It works by damaging deoxyribonucleic acid (DNA), primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. The DNA damage leads to apoptosis of the affected cells. Chemically it is a derivative of nitrogen mustard and uracil. Uracil mustard is a non-combustible substance itself; it does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidisers and may ignite combustibles – wood, paper, oil, clothing, etc. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

• 용도

  Antineoplastic.

• 일반 설명

  Creamy white crystals or off-white powder. Used as an anti-cancer medicine.

• 공기와 물의 반응

  Slightly soluble in water [Merck].

• 반응 프로필

  URACIL MUSTARD (500 MG) (FOR U.S. SALE ONLY) reacts as a base.

• 건강위험

  TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

• 화재위험

  Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

• Safety Profile

  Suspected carcinogen withexperimental carcinogenic and neoplastigenic data. Adeadly poison by ingestion and intraperitoneal routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of Cl?? and NOx.

• Carcinogenicity

  Uracil mustard was reportedly carcinogenic in both mice and rats following multiple intraperitoneal injections. It produced a dose-related increase in lung tumor incidence in mice and tumors in a variety of other organs in both mice and rats. The IARC reviewed the preceding data and deemed it “sufficient evidence of carcinogenicity in animals.” Based on this information, its mutagenic potential, analogy to other nitrogen mustards, and a lack of carcinogenicity data in humans, the IARC classified uracil mustard in Group 2B (possibly carcinogenic to humans). Uracil mustard compared to nitrogen mustard itself in the same assay (lung tumor assay in strain A mice, intraperitoneal dosing) was found to be more potent as a tumorigen than nitrogen mustard. An in vitro assay to predict carcinogenicity gave a positive response predicting that uracil mustard would be a carcinogen in rodent test models. The assay used focus formation in a stable bovine papillomavirus type 1 DNA carrying a mouse fibroblast cell line that does not require transfection, infection with virus,isolation of primary cells from animals, or addition of a microsomal fraction.

우라실 겨자 준비 용품 및 원자재

우라실 겨자 관련 검색