디벤조(A,L)피렌

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H318：눈에 심한 손상을 일으킴

  H341：유전적인 결함을 일으킬 것으로 의심됨 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재)

  H350：암을 일으킬 수 있음 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재)

• 예방조치문구

  P202：모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

  P308+P313：노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.

  P405：밀봉하여 저장하시오.

  P501：...에 내용물 / 용기를 폐기 하시오.

디벤조(A,L)피렌 화학적 특성, 용도, 생산

• 화학적 성질

  Yellow Solid

• 용도

  An active metabolite from inhalation and dermal exposure to polycyclic aromatics hydrocarbons in hot mix asphalt paving workers. DBC is the most potent tumorigen that has been identified to date. Dib enzo[def,p]chrysene (DBC) is a carcinogen and should be handled with appropriate caution.

• 일반 설명

  Yellow odorless crystals or flakes. Water insoluble.

• 공기와 물의 반응

  Dust/air mixtures may ignite and explode. Insoluble in water.

• 반응 프로필

  Vigorous reactions, sometimes amounting to explosions, can result from the contact between aromatic hydrocarbons, such as DIBENZO(A,I)PYRENE, and strong oxidizing agents. They can react exothermically with bases and with diazo compounds. Substitution at the benzene nucleus occurs by halogenation (acid catalyst), nitration, sulfonation, and the Friedel-Crafts reaction.

• Safety Profile

  Confirmed carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.

• Carcinogenicity

  Dibenzo[a,1]pyrene is a class 2B carcinogen according to the IARC, although recent data suggest that it is a 2A carcinogen. In mouse studies, it has been more potent than benzo[a]pyrene in skin, and in rat studies, it has been more potent than 7,12-dimethylbenz [a]anthracene in the mammary gland. Dibenzo[a,l]pyrene was tested for carcinogenicity in studies of single and repeated dermal application to mice, as well as several initiation–promotion studies on mouse skin; all studies gave positive results. Dibenzo[a,l] pyrene also induced oral cavity tumors when applied dermally to the tongue of hamsters and lung tumors in mice following intraperitoneal injection. In addition to lung tumors, dibenzo[a,l]pyrene induced hepatic tumors and a variety of tumors at other sites when administered intraperitoneally to newborn mice. Multiple tumor sites were also observed following intragastric application of dibenzo[a,l]pyrene in mice. Intramamillary administration to rats also yielded positive results. Furthermore, two studies on fish demonstrated that nonmammalian species are also susceptible to dibenzo[a,l]pyreneinduced tumorigenicity.The most active metabolite is the potent 11,12-dihydrodiol of dibenzo[a,1] pyrene.

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