Zaltoprofen

Zaltoprofen 화학적 특성, 용도, 생산

• 개요

  Zaltoprofen is a potent non-steroidal antiinflammatory drug (NSAID) with analgesic activity. In rats and mice, zaltoprofen is reported to be equipotent or superior to other NSAlDs in bradykinin-induced pain, acetic acid-induced writhing, carrageenan-induced hyperalgesia, and in several other experimental models of analgesia. It acts by selectively suppressing the production of prostaglandins at the inflammatory site and not in other organs such as stomach and kidney, therefore, has remarkably low gastric side effects that are associated with conventional antiinflammatory agents.

• 화학적 성질

  Off-White to Pale Yellow Crystalline Solid

• 용도

  Anti-inflammatory activity resides in (S)-enantiomer

• Synthesis

  The cyclization of 5-(1- cyanoethyl)-2-(phenylthio)phenylacetic acid in presence of polyphosphoric acid at 120 ℃ gives 2-(10-oxo-10,11-dihydrodibenzo[b,f ]thiepin- 2-yl)propionitrile, which is then hydrolyzed with KOH in refluxing ethanol – water to zaltoprofen.
  

  

Zaltoprofen 준비 용품 및 원자재

Zaltoprofen 공급 업체

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