Anti-Protein Inhibitor of Activated STAT 3

Anti-Protein Inhibitor of Activated STAT 3 화학적 특성, 용도, 생산

• 용도

  Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
  Immunofluorescence (1 paper)
  Immunohistochemistry (1 paper)

• 일반 설명

  This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. (provided by RefSeq)

• Biochem/physiol Actions

  Protein inhibitor of activated STAT protein 3 (PIAS3) and other members of this family can act as small ubiquitin-like modifier (SUMO) E3 ligases and interfere with the transcription activity of many transcription factors. PIAS3 binds to microphthalmia-associated transcription factor (MITF), a key DNA-binding protein. It blocks MITF DNA-binding activity and co-expression of MITF. PIAS3 in NIH 3T3 cells inhibits MITF-driven transcription activity.

Anti-Protein Inhibitor of Activated STAT 3 공급 업체

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