Azilsartan

한글명:Azilsartan

카스 번호147403-03-0

상품명:Azilsartan

CBNumberCB21090899

분자식C25H20N4O5

포뮬러 무게456.45

MOL 파일147403-03-0.mol

화학적 성질

녹는점	188 °C(dec.)
밀도	1.42
저장 조건	Sealed in dry,2-8°C
용해도	DMSO: 가용성15mg/mL(투명 용액)
물리적 상태	가루
산도 계수 (pKa)	2.05±0.10(Predicted)
색상	흰색에서 베이지색
InChIKey	KGSXMPPBFPAXLY-UHFFFAOYSA-N

위험 및 안전 성명

WGK 독일	3
HS 번호	2934.99.4400
유해 물질 데이터	147403-03-0(Hazardous Substances Data)

그림문자(GHS)

Azilsartan 화학적 특성, 용도, 생산

개요
Azilsartan is an antagonist of the angiotensin II type 1 receptor (AT₁; IC₅₀ = 0.42 μM) and the active metabolite of azilsartan medoxomil . Azilsartan is formed from azilsartan medoxomil by hydrolysis in the gastrointestinal tract and liver. Azilsartan also acts as an inverse agonist, inhibiting angiotensin II-induced accumulation of inositol-1-phosphate in COS-7 cells expressing recombinant human AT₁ (IC₅₀ = 2.6 nM). It reduces the maximal contractile response induced by angiotensin II in isolated rabbit aortic strips (pD₂ = 9.9). Azilsartan (100 ng/kg, i.v.) inhibits the angiotensin II-induced pressor response in conscious normotensive rats.
화학적 성질
White to Off-White Solid
용도
Azilsartan is an analgesic and antiinflammatory drugs containing angiotensin II antagonists.
정의
ChEBI: A benzimidazolecarboxylic acid that is benzimidazole-7-carboxylic acid substituted at position 2 by a methoxy group and at position 1 by a 2'-[(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl group. Used (as the prodrug, azilsartan medoxomil) f r treatment of hypertension.
Clinical Use
Azilsartan is an orally active angiotensin II blocker which was approved and launched in Japan for the treatment of arterial hypertension in May 2012. Azilsartan, which is marketed under the trade name Azilva®, was discovered and developed by Takeda—the same firm which had developed and launched a prodrug of azilsartan (azilsartan kamedoxomil, Edarbi®) in 2010. Azilsartan exhibits higher potency and slower off-rate kinetics for type 1 angiotensin II receptors, which contributes to azilsartan’s comparatively improved blood pressure lowering effect.

Azilsartan 준비 용품 및 원자재

Azilsartan 공급 업체

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