Pregnenolone

한글명:Pregnenolone

카스 번호145-13-1

상품명:Pregnenolone

CBNumberCB1684326

분자식C21H32O2

포뮬러 무게316.48

MOL 파일145-13-1.mol

화학적 성질

녹는점	188-190 °C
알파	28.5 º (c=1, EtOH)
끓는 점	395.89°C (rough estimate)
밀도	1.0382 (rough estimate)
증기압	0-0Pa at 20-25℃
굴절률	1.5344 (estimate)
인화점	9℃
저장 조건	Refrigerator
용해도	에탄올: 용해성10mg/mL, 투명, 무색 내지 희미한 노란색
물리적 상태	가루
산도 계수 (pKa)	15.00±0.70(Predicted)
색상	흰색에서 황백색까지
수용성	41mg/L(상온)
Merck	7733
BRN	2059026
InChIKey	ORNBQBCIOKFOEO-QGVNFLHTSA-N
LogP	4.4 at 20℃
CAS 데이터베이스	145-13-1(CAS DataBase Reference)
NIST	Pregnenolone(145-13-1)

위험 및 안전 성명

안전지침서	22-24/25
유엔번호(UN No.)	UN 1648 3 / PGII
WGK 독일	3
RTECS 번호	TU5560700
HS 번호	29372900

그림문자(GHS)

Pregnenolone 화학적 특성, 용도, 생산

개요
Pregnenolone serves as the common precursor in the formation of the adrenocorticoids and other steroid hormones. This C21 steroid is converted via enzymatic oxidations and isomerization of the double bond to a number of physiologically active C21 steroids, including the female sex hormone progesterone and the adrenocorticoids hydrocortisone (cortisol), corticosterone, and aldosterone. Oxidative cleavage of the two-carbon side chain of pregnenolone and subsequent enzymatic oxidations and isomerization lead to C19 steroids, including the androgens testosterone and dihydrotestosterone. The final group of steroids, the C18 female sex hormones, are derived from oxidative aromatization of the A ring of androgens to produce estrogens.
화학적 성질
white to off-white powder
용도
Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA an tagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A
정의
ChEBI: A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.
일반 설명
Pregnenolone is an endogenous steroid hormone involved in the biological synthesis of other hormones. Pregnenolone is monitored as an ancillary test for congenital adrenal hyperplasia (CAH), particularly in situations where diagnosis of 21-hydroxylase and 11-hydroxylase deficiency has been ruled out. This Certified Spiking Solution^? is suitable for use in LC-MS/MS testing methods as a starting material in the preparation of calibrators, controls and linearity standards.

Pregnenolone 준비 용품 및 원자재

Pregnenolone 공급 업체

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