클로에스테롤 아세트산

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P301+P312：삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

클로에스테롤 아세트산 MSDS

• 3beta-Hydroxy-5-cholestene 3-acetate

클로에스테롤 아세트산 화학적 특성, 용도, 생산

• 화학적 성질

  white fine crystalline powder or needles

• 용도

  Cholesteryl acetate is used in cosmetics, wrist watches, thermometers, propane tank volume indicators, video displays, pharmaceuticals.

• 정의

  ChEBI: Cholesteryl acetate is a cholesterol ester obtained by formal acylation of the hydroxy group of cholesterol by acetic acid. It has a role as a human metabolite. It is a cholesteryl ester and an acetate ester.

• 제조 방법

  Cholesteryl acetate can be synthesized by the reaction of cholesterol with acetic anhydride in the presence of a catalyst such as pyridine or sulfuric acid. The reaction proceeds as follows:
  Cholesterol + Acetic anhydride → Cholesteryl acetate + Acetic acid
  The reaction is typically carried out at room temperature or slightly elevated temperatures for several hours. The resulting cholesteryl acetate can be purified by recrystallization from a suitable solvent such as ethanol or acetone.

• 화학 반응

  Monophthalic acid epoxidation of cholesteryl acetate:
  A solution of 10 g (0.023 mole) of cholesteryl acetate (mp 112-114°) in ether (50 ml) is mixed with a solution containing 8.4 g (0.046 mole) of monophthalic acid (Chap. 17, Sec. II) in 250 ml of ether. The solution is kept at reflux for 6 hours and then the solvent is removed by distillation (steam bath). The residue is dried under vacuum and digested with 250 ml of dry chloroform. The mixture was filtered to give 6.7 g of phthalic acid (87% recovery). The solvent in the filtrate was evaporated under reduced pressure and the residue was crystallised from 30 ml of methanol to give 6.0 g (58% yield) of β-oxocholesterol acetate. Recrystallisation gives the pure product, melting point 111-112°. Concentration of the filtrate gives 1.55 g (15 per cent yield) of α-oxocholesterol acetate with a melting point of 101-103° after crystallisation from ethanol.
  

• Purification Methods

  Crystallise the acetate from n-pentanol or Me2CO. Also purify it by chromatography through silica gel and eluting with MeOH. [Beilstein 6 III 2607, 6 IV 4004.]

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