Erythromycin Estolate

한글명:Erythromycin Estolate

카스 번호3521-62-8

상품명:Erythromycin Estolate

CBNumberCB1286137

분자식C52H97NO18S

포뮬러 무게1056.39

MOL 파일3521-62-8.mol

화학적 성질

녹는점	135-140°C dec.
끓는 점	743℃
밀도	1.0053 (rough estimate)
굴절률	1.6550 (estimate)
인화점	>110°(230°F)
저장 조건	Keep in dark place,Sealed in dry,Room Temperature
용해도	클로로포름: 용해성4.0ML, 투명, 무색(200mg + 4.0mL 클로로포름)
물리적 상태	Solid
산도 계수 (pKa)	6.9(at 25℃)
색상	하얀색
수용성	Freely soluble in organic solvents, practically insoluble in water /n
감도	Light Sensitive
CAS 데이터베이스	3521-62-8

위험 및 안전 성명

위험품 표기	Xn,Xi
위험 카페고리 넘버	22-42/43-36/37/38
안전지침서	22-36-26
WGK 독일	3
RTECS 번호	KF5775000
HS 번호	29419000
독성	LD50 orally in rats: >5000 mg/kg (Goldenthal)

그림문자(GHS)

Erythromycin Estolate MSDS

Erythromycin Estolate 화학적 특성, 용도, 생산

개요
Erythromycin estolate was synthesized by the Lilly Research Laboratories in 1959. It shows a higher and longer lasting serum level than erythromycin and the other esters, ethylsuccinate and stearate, when administered orally. This antibiotic is stable against gastric acids, and after oral absorption it is hydrolyzed gradually into erythromycin. Long-term usage of erythromycin estolate is toxic to the liver. Erythromycin ethylsuccinate [41342-53-4], (C43H75NO16, Mr 862.07) and erythromycin stearate [643-22-1] (C37H67NO13 · C18H36O2, Mr 1018.43) also have been used orally, and erythromycin lactobionate [3847-29-8] (C37H67NO13 · C12H22NO12, Mr 1092.25) has been used by intravenous administration and opthalmic topical application
화학적 성질
Long Needles
World Health Organization (WHO)
Erythromycin estolate, a macrolide antibiotic, was introduced in 1958 for the treatment of gram-positive infections. By the early 1970s its use had been associated with a higher incidence of hepatic toxicity than that seen with other salts and esters of erythromycin. This led to its withdrawal by some regulatory authorities whereas others required the addition of a warning in the product information. Evidence that the estolate ester is more hepatotoxic than other salts or esters has subsequently been disputed. It has been claimed to be the most effective ester for treatment of Legionnaire's disease and preparations remain widely available. (Reference: (BMJOAE) British Medical Journal, 286, 1954, 1983)
일반 설명
Erythromycin estolate, erythromycin propionate lauryl sulfate(Ilosone), is the lauryl sulfate salt of the 2＇-propionateester of erythromycin. Erythromycin estolate is acid stableand absorbed as the propionate ester. The ester undergoesslow hydrolysis in vivo. Only the free base binds to bacterialribosomes. Some evidence, however, suggests that theester is taken up by bacterial cells more rapidly than thefree base and undergoes hydrolysis by bacterial esteraseswithin the cells. The incidence of cholestatic hepatitis is reportedlyhigher with the estolate than with other erythromycinpreparations.
Erythromycin estolate occurs as long needles that aresparingly soluble in water but soluble in organic solvents. administration for the treatment of serious infections,such as Legionnaires disease, or when oral administrationis not possible. Solutions are stable for 1 week whenrefrigerated.

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