Monoclonal Anti-Pan Cadherin antibody produced in mouse has been used in:
fluorescence imaging
immunohistochemistry
western blotting
immunoblotting
immunofluorescence
일반 설명
Neural-cadherin (N-cadherin) is a member of the classic cadherin family. It is mainly expressed in neural and mesenchymal tissues.
Biochem/physiol Actions
Neural-cadherin (N-cadherin) has an oncogenic role in bladder cancer,?breast cancer, prostate cancer and melanoma. It stimulates the heterotypic adhesion of melanoma cells to dermal fibroblast cells. N-cadherin?acts as a critical modulator for the migration of neuronal progenitors. It is essential for the proper cohesion and?polarisation?of?neuroepithelial cells. N-cadherin is important for normal gastrulation and neural crest development. It is required for myogenesis and myotube formation.
