칼콘

한글명:칼콘

카스 번호94-41-7

상품명:Chalcone

CBNumberCB0746254

분자식C15H12O

포뮬러 무게208.26

MOL 파일94-41-7.mol

동의어(한글)

칼콘

화학적 성질

녹는점	55-59 °C
끓는 점	208 °C25 mm Hg(lit.)
밀도	d462 1.0712
굴절률	nD62 1.6458
인화점	>230 °F
저장 조건	Sealed in dry,Room Temperature
용해도	디옥산: 용해성1g/10mL, 투명, 무색
물리적 상태	과립분말
색상	노란색
Merck	14,2037
BRN	1210466
LogP	3.080
CAS 데이터베이스	94-41-7(CAS DataBase Reference)
EPA	2-Propen-1-one, 1,3-diphenyl- (94-41-7)

위험 및 안전 성명

위험품 표기

Xn,Xi

위험 카페고리 넘버

22-36/37

안전지침서

22-36/37/39-45

WGK 독일

RTECS 번호

UD5576750

HS 번호

29143900

NFPA 704:

	1
2		0

그림문자(GHS)

칼콘 화학적 특성, 용도, 생산

개요
Chalcone is the organic compound C6H5C(O)CH=CHC6H5. It is an α,β-unsaturated ketone. A variety of important biological compounds are known collectively as chalcones or chalconoids.They show antibacterial, antifungal, antitumor and anti-inflammatory properties. They are also intermediates in the biosynthesis of flavonoids, which are substances widespread in plants and with an array of biological activities. Chalcones are also intermediates in the Auwers synthesis of flavones.
화학적 성질
light yellow powder
용도
Chalcone is used in the preparation of pharmacologically-interesting heterocyclic systems like pyrazolines and pyrimidines. It also inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase.
정의
ChEBI: A member of the class of chalcones that is acetophenone in which one of the methyl hydrogens has been replaced by a benzylidene group.
제조 방법
Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
Chalcones can be prepared by an aldol condensation between a benzaldehyde and an acetophenone in the presence of sodium hydroxide as a catalyst.

This reaction has been found to work without any solvent at all - a solid-state reaction. The reaction between substituted benzaldehydes and acetophenones has been used to demonstrate green chemistry in undergraduate chemistry education.In a study investigating green chemistry synthesis, chalcones were also synthesized from the same starting materials in high temperature water (200 to 350 °C).
생물학적 활성
1,3-Diphenyl-2-propenone (chalcone) inhibits the proliferation of human breast cancer cell lines, MCF-7 and MDA-MB-231 by inducing apoptosis and blocking cell cycle progression in the G2/M phase. It is an inhibitor of Plasmodium falciparum cyclin-dependent protein kinases.
Safety Profile
Poison by intravenous route. See also KETONES. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
Crystallise it from EtOH by warming to 50o (about 5mL/g), iso-octane, or toluene/pet ether, or recrystallise it from MeOH, and then twice from hexane. SKIN IRRITANT. [Beilstein 7 IV 1658.]

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