갈릭산

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

갈릭산 MSDS

• 3,4,5-Trihydroxybenzoic acid

갈릭산 화학적 특성, 용도, 생산

• 순도시험

    (1) 용상 : 이 품목 1g을 20mL에 녹일 때, 그 액은 미황색으로서 탁도는 거의 징명 이하이어야 한다.

    (2) 탄닌산 : 이 품목 1g에 물 20mL를 가하여 진탕 혼합한 후 여과하여 여액에 따뜻한 젤라틴 용액(1%) 5～6방울을 가할 때, 탁하여서는 아니 된다.

    (3) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

    (4) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.

• 확인시험

    이 품목 1g에 물 20mL를 가하여 약 1분간 진탕하여 섞은 후 여과한 여액에 염화제이철용액(1→10) 2～3방울을 가할 때, 청흑색의 침전이 생긴다.

• 정의

    이 품목은 옻나무과 옻나무(Rhus javanica L.)에 발생하는 오배자, 참나무과(Quercus infectoria Oliv.)에 발생하는 몰식자를 물, 에탄올 또는 유기용제로 추출한 탄닌을 알칼리 또는 효소(탄나아제)로 가수분해하여 얻어지는 것으로서 성분은 몰식자산이다.

• 강열잔류물

    이 품목의 강열잔류물은 0.1% 이하이어야 한다.

• 개요

  Gallic acid is a trihydroxybenzoic acid, a type of phenolic acid, a type of organic acid, also known as 3,4,5- trihydroxy benzoic acid, found in gallnuts, sumac, witch hazel, tea leaves, oak bark, and other plants. The chemical formula is C₆H₂(OH)₃COOH. Gallic acid is found both free and as part of hydrolyzable tannins.
  Salts and esters of gallic acid are termed 'gallates'. Despite its name, it does not contain gallium.
  Gallic acid is commonly used in the pharmaceutical industry. It is used as a standard for determining the phenol content of various analytes by the Folin - Ciocalteau assay; results are reported in gallic acid equivalents. Gallic acid can also be used as a starting material in the synthesis of the psychedelic alkaloid mescaline.
  Gallic acid seems to have anti-fungal and antiviral properties. Gallic acid acts as an antioxidant and helps to protect human cells against oxidative damage. Gallic acid was found to show cytotoxicity against cancer cells, without harming healthy cells. Gallic acid is used as a remote astringent in cases of internal haemorrhage. Gallic acid is also used to treat albuminuria and diabetes. Some ointments to treat psoriasis and external haemorrhoids contain gallic acid.

• 화학적 성질

  Gallic acid, also known as trihydroxybenzoic acid, is a colorless crystalline needles or prisms that is obtained from nutgall tannins. It is soluble in hot water, ether, ethanol, acetone and glycerin, insoluble in cold water, insoluble in benzene and chloroform and has a melting point of 235 to 240 °C (decomposition). When heated to 100-120°C, crystal water will be lost, and when heated above 200°C, carbon dioxide will be lost to generate pyrogallic acid (ie, pyrogallol). It is used in photography, tanning, ink manufacture and pharmaceuticals.

• 출처

  Gallic acid is found in a number of land plants. It is also found in the aquatic plant Myriophyllum spicatum and shows an allelopathic effect on the growth of the blue-green alga Microcystis aeruginosa.
  In food
  Areca nut
  Bearberry (Arctostaphylos sp)
  Bergenia sp
  Blackberry
  Hot chocolate
  Juglans regia (Common walnut)
  Mango in peels and leaves
  Phyllanthus emblica (Indian gooseberry) in fruits
  Raspberry
  Syzygium aromaticum (clove)
  Vinegar
  wine
  Witch hazel (Hamamelis virginiana)
  White tea.

• 역사

  Gallic acid is an important component of iron gall ink, the standard European writing and drawing ink from the 12 th to 19th century with a history extending to the Roman empire and the Dead Sea Scrolls. Pliny the Elder (23-79 AD) describes his experiments with it and writes that it was used to produce dyes. Galls (also known as oak apples) from oak trees were crushed and mixed with water, producing tannic acid (a macromolecular complex containing gallic acid). It could then be mixed with green vitriol (ferrous sulfate) — obtained by allowing sulfate - saturated water from a spring or mine drainage to evaporate — and gum arabic from acacia trees; this combination of ingredients produced the ink.
  Gallic acid was one of the substances used by Angelo Mai (1782–1854), among other early investigators of palimpsests, to clear the top layer of text off and reveal hidden manuscripts underneath. Mai was the first to employ it, but did so "with a heavy hand", often rendering manuscripts too damaged for subsequent study by other researchers.
  Early photographers, including Joseph Bancroft Reade (1801– 1870) and William Fox Talbot (1800 – 1877), used gallic acid for developing latent images in calotypes. It has also been used as a coating agent in zincography.

• 용도

  gallic acid is a potential bleaching agent and anti-oxidant, it is also astringent and potentially anti-microbial and anti-fungal. Scientists are finding that gallic acid may serve as a skin-lightening agent by inhibiting the action of the tyrosinase and peroxidase enzymes. Some studies indicate that it is more effective than hydroquinone when combined with the proper ingredients. It is also incorporated into anti-aging formulations for its ability to prevent mucopolysaccaride deterioration. It is a constituent of witch hazel and oak bark, among many other plants; however, it is generally obtained from nutgalls for commercial purposes.

• 생산 방법

  Gallic acid, a component of many tanning agents is an endogenous product in plants. The acid occurs free or bound to tannin [1401-55-4] (e.g., in divi-divi, oak bark, gallnuts, pomegranate roots, sumac, and tea). The acid is produced from tannin-rich aqueous gallnut extracts by acidic or alkaline hydrolysis. It is also obtained by using the enzyme tannase [9025-71- 2] or molds (Penicillium glaucum, Aspergillus niger) to cleave tannin by fermentation. Both the metabolism of gallic acid and its impact on plant growth enzymes have been studied.

• 정의

  ChEBI: Gallic acid is a trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5. It has a role as an astringent, a cyclooxygenase 2 inhibitor, a plant metabolite, an antioxidant, an antineoplastic agent, a human xenobiotic metabolite, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor, an apoptosis inducer and a geroprotector. It is a conjugate acid of a gallate.

• 일반 설명

  Gallic acid is a phenol that has been found in C. sinensis and has diverse biological activities. It scavenges DPPH and hydroxyl radicals in cell-free assays (IC50s = 9.4 and 191 μM, respectively). Gallic acid (1-100 μM) reverses abscisic acid-induced inhibition of hypocotyl growth in A. caudatus seedlings. In vivo, gallic acid (21.8 g/kg) inhibits morpholine- and sodium nitrite-induced adenocarcinoma formation in mice. It also inhibits passive cutaneous anaphylaxis in mice when administered at a dose of 50 mg/kg.

• 공기와 물의 반응

  Sparingly water soluble

• 반응 프로필

  Phenols, such as Gallic acid, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid.

• 건강위험

  Inhalation of dust may irritate nose and throat. Contact with eyes or skin causes irritation.

• 화재위험

  Flash point data for Gallic acid are not available. Gallic acid is probably combustible.

• 부작용

  It is a weak carbonic anhydrase inhibitor.

• 신진 대사

  Biosynthesis
  Chemical structure of 3,5- didehydro shikimate Gallic acid is formed from 3-dehydro shikimate by the action of the enzyme shikimate dehydro genase to produce 3,5-didehydro shikimate. This latter compound tautomerizes to form the redox equivalent gallic acid, where the equilibrium lies essentially entirely toward gallic acid because of the coincidently occurring aromatization.
  Degradation
  Gallate dioxygenase is an enzyme found in Pseudomonas putida that catalyzes the reaction :
  gallate + O₂ → (1E)-4-oxobut-1-ene-1,2,4-tri carboxylate.
  Gallate decarboxylase is another enzyme in the degradation of gallic acid.
  Conjugation
  Gallate 1-beta-glucosyltransferase is an enzyme that uses UDPglucose and gallate, whereas its two products are UDP and 1-galloylbeta- D-glucose.

• Purification Methods

  Crystallise gallic from water. The tri-O-acetyl derivative has m 172o (from MeOH), and the anilide has m 207o(from EtOH). [Beilstein 10 H 470, 10 IV 1993.]

• 참고 문헌

  Plant polyphenols (vegetable tannins): gallic acid metabolism. DOI:10.1039/NP9941100041
  Biotechnology of Food and Feed Additives DOI:10.1007/978-3-662-43761-2
  Purification of Laboratory Chemicals  DOI:10.5860/choice.50-6768
  Gallic acid: a versatile antioxidant with promising therapeutic and industrial applications DOI:10.1039/C5RA01911G
  Antioxidant properties and total phenolics content of green and black tea under different brewing conditions DOI:10.1007/S002170050406
  Comparative study of eight well‐known polyphenolic antioxidants DOI:10.1211/0022357021693
  Antagonistic Action of Phenolic Compounds on Abscisic Acid-Induced Inhibition of Hypocotyl Growth DOI:10.1093/JXB/31.6.1651

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