Clevidipine butyrate

한글명:Clevidipine butyrate

카스 번호167221-71-8

상품명:Clevidipine butyrate

CBNumberCB01248667

분자식C21H23Cl2NO6

포뮬러 무게456.32

MOL 파일167221-71-8.mol

화학적 성질

녹는점	128-130°C
끓는 점	539.7±50.0 °C(Predicted)
밀도	1.289
인화점	280℃
저장 조건	Keep in dark place,Inert atmosphere,2-8°C
용해도	Insoluble[in water]
수용성	물에 불용성
용해도	≥21.4 mg/mL in DMSO; insoluble in H2O; ≥7.45 mg/mL in EtOH with ultrasonic
물리적 상태	powder to crystal
산도 계수 (pKa)	2.45±0.70(Predicted)
색상	흰색에서 밝은 노란색
CAS 데이터베이스	167221-71-8

위험 및 안전 성명

안전지침서

24/25

HS 번호

29339900

NFPA 704:

	0
2		0

그림문자(GHS)

Clevidipine butyrate 화학적 특성, 용도, 생산

개요
Clevidipine is an ultra-short-acting vasodilator of the dihydropyridine (DHP) class of CCB. It is indicated as an intravenous treatment for the acute management of hypertension when oral therapy is not feasible or not desirable. Clevidipine is the second intravenous CCB to be marketed behind nicardipine for this indication. Both agents are primarily used for urgent treatment of hypertension in cardiac surgical setting, intensive care units, and emergency departments. Other intravenous agents currently on the market for this indication include sodium nitroprusside, nitroglycerin, fenoldopam, hydralazine, esmolol, and labetalol. Clevidipine is a potent, arterial-specific, vasodilator with very little or no effect on the myocardial contractility and venous capacitance. It has a rapid onset and offset of action and a very short plasma half-life, which allows for titration of the drug to achieve precise BP control.
clevidipine is exclusively metabolized in the blood and the tissues. It does not undergo any renal or hepatic metabolism and does not accumulate in the body. Clevidipine is a blocker of L-type calcium channels, which mediate the influx of calcium during depolarization in arterial smooth muscle.
화학적 성질
White to Off-White Solid
용도
Clevidipine butyrate is a dihydropyridine calcium channel blocker use as agent for the reduction of blood pressure。
부작용
Clevidipine is contraindicated in patients with severe aortic stenosis, defective lipid metabolism, and allergies to eggs, egg products, soybeans, or soy products. The chemical synthesis of clevidipine entails the esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester with chloromethyl butyrate by the action of potassium bicarbonate in refluxing acetonitrile.

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