クロロぎ酸プロピル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H225：引火性の高い液体および蒸気

  H302：飲み込むと有害

  H314：重篤な皮膚の薬傷?眼の損傷

  H331：吸入すると有毒

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P303+P361+P353：皮膚（または髪）に付着した場合：直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

クロロぎ酸プロピル 価格

クロロぎ酸プロピル 化学特性,用途語,生産方法

• 外観

  無色～うすい黄色、液体

• 用途

  有機合成原料。

• 化学的特性

  Propyl Chloroformate (PCF) is a colorless to yellow liquid, with a pungent odor. It reacts with water and spontaneous decomposes. It is miscible with benzene and ether.

• 使用

  Propyl Chloroformate is used as a dramatizing agent for the determination of morphine, codeine and 6-acetyl morphine in urine and blood using direct aqueous derivatization.

• 調製方法

  Prepared by the reaction of liquid anhydrous n-propyl alcohol with molar excess of dry, chlorine-free phosgene at low temperature.

• 主な応用

  Propyl chloroformate has been used:
  as derivatization reagent in quantification of dopamine, serotonin and norepinephrine in human urine by solid phase microextraction-gas chromatography-triple quadrupole mass spectrometry
  in the preparation of dipropyl 3,6-diphenyl-1,2-dihydro-1,2,4,5-tetrazine-1,2-dicarboxylate
  N-propyl chloroformate is an intermediate of the fungicide propamocarb.

• 製造方法

  Synthesis of Propyl chloroformate: Add n-propanol to the phosgene-passing kettle, start stirring, and then pass phosgene through the phosgene flowmeter. The phosgene-passing temperature is about 30 °C, and continue to pass the phosgene for several hours. When the end point is approached, sample and analyze, and stop when the standard is reached. Pass phosgene, cool, and then pass nitrogen to drive away phosgene and hydrogen chloride, destroy phosgene, and sample and analyze it as a product.
  Reaction equation: CH3CH2CH2OH+COCl2→ClCOOCH2CH2CH3

• 一般的な説明

  N-propyl chloroformate appears as a colorless liquid. May be decomposed by water. Severely irritates skin and eyes. Very toxic by ingestion, inhalation or skin absorption. Denser than water and vapors heavier than air. Flash point 50°F. Used to make other chemicals.

• 空気と水の反応

  Highly flammable. Water (moisture in air or soil) reacts with generation of heat and hydrochloric acid.

• 反応プロフィール

  Unstable, decomposes spontaneously to form hydrochloric acid and other products. Avoid moist air. [EPA, 1998]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

• 健康ハザード

  Strongly irritating to eyes and mucous membranes. Poisonous; may be fatal if inhaled, swallowed or absorbed through skin.

• 火災危険

  When heated to decomposition, Propyl chloroformate emits toxic fumes of chlorine containing compounds. Propyl chloroformate is a flammable/combustible material; Propyl chloroformate may be ignited by heat, sparks or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat or fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Runoff from fire control or dilution water may cause pollution. Gradually decomposed by water and alcohol. Unstable, decomposes spontaneously to form hydrochloric acid and other products. Avoid moist air.

• 安全性プロファイル

  Poison by skin contact. Moderately toxic by ingestion and inhalation. A corrosive irritant to skin, eyes, and mucous membranes. Flammable when exposed to heat or flame, can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of Cl-. Used as a reactive intermediate to polymerization initiators.

• 職業ばく露

  Propyl chloroformate is used in organic synthesis; as an intermediate for polymerization initiators; may have been used as a military poison gas.

• 輸送方法

  UN2740 n-Propyl chloroformate, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, 8-Corrosive material. Inhalation Hazard Zone B

• 不和合性

  Propyl chloroformate forms explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, water and alcohols. Reaction with water forms heat and hydrochloric acid. Attacks some metals and coating in the presence of moisture.

クロロぎ酸プロピル 上流と下流の製品情報

クロロぎ酸プロピル 生産企業

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クロロぎ酸プロピル スペクトルデータ(¹HNMR、¹³CNMR、IR1、MS、Raman)

109-61-5, クロロぎ酸プロピル キーワード