KI16425

KI16425 価格

KI16425 化学特性,用途語,生産方法

• 外観

  白色～わずかにうすい褐色、結晶～粉末

• 溶解性

  エタノールに溶ける。

• 説明

  Lysophosphatidic acid (LPA) is a bioactive lipid mediator that signals through five distinct G protein-coupled receptors (LPA_1-5). Ki16425 is a LPA receptor antagonist with selectivity for LPA₁ and LPA₃. It exhibits K_i values of 0.34, 6.5, and 0.93 μM for the human LPA₁, LPA₂, and LPA₃ receptors, respectively, as determined by measuring inositol phosphate production in RH7777-transfected cells. Ki1642, at 10 μM, significantly blocks the response of a variety of cancer cell lines to LPA-induced cell migration.

• 使用

  Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3.

• Biochem/physiol Actions

  Ki 16425 possesses a short-lived inhibitory activity. It has been studied that Ki 16425 is effective in the inhibition of neuropathic pain‐like behaviors.

KI16425 生産企業

Global(107)Suppliers

KI16425 スペクトルデータ(¹HNMR)

355025-24-0, KI16425 キーワード