N-(3-イソプロポキシフェニル)-2-(トリフルオロメチル)ベンズアミド

化学名:N-(3-イソプロポキシフェニル)-2-(トリフルオロメチル)ベンズアミド

英語名:Flutolanil

CBNumberCB9478268

MFC17H16F3NO2

MW323.31

别名

3'-イソプロポキシ-2-トリフルオロメチルベンズアニリド

フルトラニル

フルタラニル

N-(3-イソプロポキシフェニル)-2-(トリフルオロメチル)ベンズアミド物理性質

融点	108° (Araki, Yabutani); mp 104-105° (Araki, 1985)
沸点	339.1±42.0 °C(Predicted)
比重(密度)	1.2463 (estimate)
蒸気圧	6.5 x 10^-6 Pa (25 °C)
貯蔵温度	0-6°C
溶解性	クロロホルム（微量）、メタノール（微量）
外見	個体
水溶解度	6.53 mg l^-1 (20 °C)
酸解離定数(Pka)	12.44±0.70(Predicted)
色	白から淡いオレンジ
InChI	InChI=1S/C17H16F3NO2/c1-11(2)23-13-7-5-6-12(10-13)21-16(22)14-8-3-4-9-15(14)17(18,19)20/h3-11H,1-2H3,(H,21,22)
InChIKey	PTCGDEVVHUXTMP-UHFFFAOYSA-N
SMILES	C(NC1=CC=CC(OC(C)C)=C1)(=O)C1=CC=CC=C1C(F)(F)F
LogP	3.700
EPAの化学物質情報	Flutolanil (66332-96-5)

安全性情報

RTECS 番号	CV5581320
有毒物質データの	66332-96-5(Hazardous Substances Data)
毒性	LD50 in male and female rats, male and female mice (mg/kg): >10,000, >10,000 orally; in male and female rats (mg/kg): >5000 dermally (Araki)
消防法	危-4-1-II
化審法	一般化学物質
安衛法	57,57-2
PRTR法	第1種指定化学物質

危険有害性情報のコード(GHS)

外観
白色の結晶性粉末
溶解性
アセトンに溶け、水にほとんど溶けない。
用途
農薬(殺菌剤)
農薬用途
殺菌剤
使用
Flutolanil is used to control Basidiomycetes diseases in rice, cereals, sugar beet and other crops.
作用机制
複合体Ⅱ（コハク酸脱水素酵素）を阻害
製品名
MONCUT
安全性プロファイル
Low toxicity by ingestion, skincontact, intraperitoneal, and subcutaneous routes. Whenheated to decomposition it emits toxic vapors of NOx andF??.
代謝経路
Flutolanil is an analogue of mepronil in which the methyl group is replaced by trifluoromethyl. Both compounds have systemic activity. This change in structure should render flutolanil more biostable by hindering hydrolysis and removing the option of methyl hydroxylation and further oxidation. This seems to be borne out in practice in that most of the metabolism of flutolanil occurs via O-dealkylation and aryl hydroxylation. Hydrolysis has not been detected.
Mode of action
Flutolanil is a SDHI (Succinate-dehydrogenase inhibitor) with narrow spectrum. Flutolanil has inhibitory effect against development of each step of the infection cycle. Inhibition of invasion from sclerotium and mycelial growth result in preventive and curative effect in infection, respectively。