Lysine-specific Demethylase Inhibitor (1C)

Lysine-specific Demethylase Inhibitor (1C) 化学特性,用途語,生産方法

• 一般的な説明

  A bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 μM in vitro, and is shown to significantly increase methylation at the histone 3 lysine 4 chromatin mark (H3K4me1 and H3K4me2) dose-dependently from 0.25 μM to 10 μM, without affecting global H3K9me2 (which is not a LSD1 substrate) levels in HCT116 human colon carcinoma cells. This compound induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5.

Lysine-specific Demethylase Inhibitor (1C) 生産企業

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