2-ニトロフルオレン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H351：発がんのおそれの疑い

  H411：長期的影響により水生生物に毒性

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P273：環境への放出を避けること。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

2-ニトロフルオレン 価格

MSDS Information

• 2-Nitrofluorene

2-ニトロフルオレン 化学特性,用途語,生産方法

• 外観

  僅かにうすい黄色～黄色、結晶性粉末～粉末

• 溶解性

  エタノール及びアセトンに溶け、水にほとんど溶けない。

• 用途

  有機合成原料。

• 用途

  合成中間体、実験用発がん物質

• 化学的特性

  cream powder

• 使用

  2-Nitrofluorene is a genotoxic compound and also a biomaker that affects the DNA of living organisms. An environmental pollutant.

• 定義

  ChEBI: A nitroarene that is fluorene substituted by a nitro group at position 2.

• 一般的な説明

  Cream-colored solid.

• 空気と水の反応

  Insoluble in water.

• 反応プロフィール

  Aromatic nitro compounds, such as 2-Nitrofluorene, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups. Stable under normal conditions. Protect from bases.

• 健康ハザード

  ACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products. Carcinogen.

• 安全性プロファイル

  Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.

• 代謝経路

  Lung microsomal metabolism of 2-nitrofluorene (NF) increases in parallel with the accumulation of P-450b homologous mRNA and microsomal cytochrome P- 450b protein concentration. The formation of the major metabolite, and potent mutagen, 9-hydroxy-2- nitrofluorene (9-OHNF) is significantly inhibited by the addition of polyclonal anti-P-450b-IgG, and by the addition of the inhibitor, proadifen, to incubations with lung microsomal protein.

• 純化方法

  Crystallise 2-nitrofluorene from aqueous acetic acid or Me2CO (m 158-158.5o, also 160-160.5o). [Beilstein 5 H 628, 5 III 1948.]

2-ニトロフルオレン 上流と下流の製品情報

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