(1S,8aα)-オクタヒドロインドリジン-1β,6α,7β,8α-テトラオール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H312：皮膚に接触すると有害

  H332：吸入すると有害

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P304+P340：吸入した場合：空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。

  P321：特別な処置が必要である（このラベルの．．． を見よ）。

(1S,8aα)-オクタヒドロインドリジン-1β,6α,7β,8α-テトラオール 価格

(1S,8aα)-オクタヒドロインドリジン-1β,6α,7β,8α-テトラオール 化学特性,用途語,生産方法

• 外観

  白色〜わずかにうすい黄色, 結晶性粉末〜粉末

• 溶解性

  メタノールに溶ける。

• 用途

  糖たん白質糖鎖合成過程、生物機能の解析ツール。

• 説明

  Glucosidases catalyze the cleavage of individual glucosyl residues from various glycoconjugates, including complex carbohydrates and glycoproteins. Castanospermine is an inhibitor of both α- and β-glucosidases, inhibiting lysosomal and neutral α-glucosidases with K_i values of 0.1 and 10 μM, respectively, and lysosomal and cytosolic β-glucosidases with K_i values of 7 and 40 μM, respectively. It is effective both in vitro and in vivo. Through its effects on glucosidases, castanospermine blocks N-linked glycosylation during post-translational modification of proteins, affecting protein trafficking and cell functions that are dependent on glycosylation, including angiogenesis. Castanospermine also interferes with viral replication and infection that is dependent on glucosidase activity.

• 化学的特性

  White Crystalline Solid

• 天然物の起源

  The seeds of Castanospermum australe yield this simple alkaloid. It forms colourless crystals from EtOH and is dextrorotatory with a specific rotation of [α]D25 +79.7° (c 0.93, H20). Castano spermine has been characterized as the crystalline methiodide, m.p. 11O-112°C.

• 使用

  Castanospermine is a plant alkaloid shown to be a potent inhibitor of lysosomal a-or beta- glucosidase. It also inhibits mammalian glucosidase 1 and beta-mannosidase from sweet almonds and fungal beta-xylosidase.

• 生物活性

  Potent inhibitor of α - and β -glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.

(1S,8aα)-オクタヒドロインドリジン-1β,6α,7β,8α-テトラオール 上流と下流の製品情報

(1S,8aα)-オクタヒドロインドリジン-1β,6α,7β,8α-テトラオール 生産企業

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