PROPIONYL-L-CARNITINE HYDROCHLORIDE

PROPIONYL-L-CARNITINE HYDROCHLORIDE 価格

PROPIONYL-L-CARNITINE HYDROCHLORIDE 化学特性,用途語,生産方法

• 使用

  L-Propionyl carnitine has been shown to improve the heart mechanical recovery and other metabolic parameters after ischemia-reperfusion

• 一般的な説明

  Propionyl-L-carnitine (PLC), a natural odd-carbon-number, endogenous ester of L-carnitine, is found to be present in humans and animals as a minor component compared to L-carnitine (LC) and acetyl-L-carnitine (ALC). It acts as a carrier of long chain acyl groups from activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix where they undergo β-oxidation to acetyl CoA to obtain usable energy via the citric acid cycle.

• Biochem/physiol Actions

  Propionyl-L-carnitine (PLC) plays a key role in lipid and carbohydrate metabolism. It provides substrates to the ischemic muscle for energy production and ATP generation. PLC has the potential to treat severe peripheral arterial disease and chronic heart failure. It is present in high abundance in the urine of patients with methylmalonyl-CoA mutase (MUT) deficiency, together with methylmalonic acid. MUT is a mitochondrial enzyme that catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA.

PROPIONYL-L-CARNITINE HYDROCHLORIDE 生産企業

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20064-19-1, PROPIONYL-L-CARNITINE HYDROCHLORIDE キーワード