1-bromo-4-methyl-2-Pentanone

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H314：重篤な皮膚の薬傷?眼の損傷

• 注意書き

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

1-bromo-4-methyl-2-Pentanone 化学特性,用途語,生産方法

• 製造方法

  Sytheisis of 1-Bromo-4-methylpentan-2-one: 4-Methylpentene (10.1 g, 120.0 mmmol) was mixed with water (500 mL) at 0 °C. Br2 (19.2 g, 120.0 mmol) was added dropwise and the mixture was stirred overnight at r.t. The mixture was extracted with pet. ether (4 x 75 mL). The organic phase was dried with MgSO4 and the solvent was evaporated under reduced pressure giving the crude product (19.15 g, brown oil). The crude product contained a mixture of 1,2 dibromo-4-methylpentane and 1-bromo-4- methylpentan-2-ol and 2-bromo-4-methylpentanol. The crude product was separated on DFC using the eluent (10% EtOAc in Hexanes) giving 1,2 dibromo-4-methylpentane (11.3 g) and a mixture of 1-bromo-4-methylpentan-2-ol and 2-bromo-4-methylpentanol (1.9 g). Chromic acid solution (12.3 mL) was added to the mixture of 1bromo-4-methylpentan-2-ol and 2- bromo-4-methylpentanol (1. 9 g) was dissolved in diethyl ether (50 mL) and the mixture was stirred overnight at r.t. Saturated NaHCO3 (aq) (200 mL) was added and the mixture was extracted with pet. ether (4 x 75 mL). The organic phase was dried with MgSO4 and the solvent was evaporated under reduced pressure giving the 1-bromo-4-methylpentan-2-one (0.72 g, brown oil, 3.3 %). The yield of this reaction was poor, but the same reaction is reported in 28% yield.
  
  Chromic acid solution was prepared (500 mL):
  Na2Cr2O7 x H2O (100 g, 0.33 mol) was dissolved in 300 mL of water. 97 % H2SO4 (136 g, 1. 34 mol) was then added. The solution was then diluted to 500 mL total volume. This solution will oxidize 1.00 mol of secondary alcohol.
  Rf = 0.44 (15% EtOAc in Hexanes)

1-bromo-4-methyl-2-Pentanone 生産企業

Global(6)Suppliers