セテアリルアルコール

セテアリルアルコール 化学特性,用途語,生産方法

• 定義

  本品は、セタノール(*)及びステアリルアルコール(*)からなる脂肪族アルコールの混合物である。
  参照表示名称：ステアリルアルコール, セタノール

• 化粧品の成分用途

  不透明化剤、非水系増粘剤、起泡剤、親水性増粘剤、乳化安定剤

• 化学的特性

  Cetostearyl alcohol occurs as white or cream-colored unctuous masses, flakes, pellets or granules. It has a faint, characteristic sweet odor. On heating, cetostearyl alcohol melts to a clear, colorless or pale yellow-colored liquid free of suspended matter.

• 調製方法

  Cetostearyl alcohol is prepared by the reduction of the appropriate fatty acids from vegetable and animal sources. Cetostearyl alcohol can also be prepared directly from hydrocarbon sources.

• 応用例（製薬）

  Cetostearyl alcohol is used in cosmetics and topical pharmaceutical preparations. In topical pharmaceutical formulations, cetostearyl alcohol will increase the viscosity and act as an emulsifier in both water-in-oil and oil-in-water emulsions. Cetostearyl alcohol will stablize an emulsion and also act as a co-emulsifier, thus decreasing the total amount of surfactant required to form a stable emulsion. Cetostearyl alcohol is also used in the preparation of nonaqueous creams and sticks, and in nonlathering shaving creams. Research articles have been published in which cetostearyl alcohol has been used to control or slow the dissolution rate of tablets or microspheres containing water-soluble drugs, or poorly watersoluble drugs, as well as to stabilize amorphous systems. In combination with other surfactants, cetostearyl alcohol forms emulsions with very complex microstructures. These microstructures can include liquid crystals, lamellar structures, and gel phases.

• 安全性

  Cetostearyl alcohol is mainly used in topical pharmaceutical formulations and topical cosmetic formulations.
  Cetostearyl alcohol is generally regarded as a nontoxic material. Although it is essentially nonirritating, sensitization reactions to cetostearyl, cetyl, and stearyl alcohols have been reported.
  Gamma radiation has been shown to be feasible for sterilization of petrolatum containing cetostearyl alcohol resulting in low levels of radiolysis products, which are of low toxicity.

• 貯蔵

  Cetostearyl alcohol is stable under normal storage conditions. Cetostearyl alcohol should be stored in a well-closed container in a cool, dry place.

• 不和合性

  Incompatible with strong oxidizing agents and metal salts.

• 規制状況(Regulatory Status)

  Accepted as an indirect food additive and as an adhesive and a component of packaging coatings in the USA. Included in the FDA Inactive Ingredients Database (oral tablets; topical emulsions, lotions, ointments; vaginal suppositories). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

セテアリルアルコール 生産企業

Global(176)Suppliers

8005-44-5, セテアリルアルコール キーワード