Anti-ER degradation enhancer, mannosidase alpha-like 3

Anti-ER degradation enhancer, mannosidase alpha-like 3 化学特性,用途語,生産方法

• 使用

  Anti-EDEM3 (C-terminal) antibody produced in rabbit is suitable for immunoprecipitation at a concentration of 1-2μL using mouse 3T3 cell lysates and western blotting (at a dilution of 1:1,000-1:2,000 using whole extract of human HEK-293T cells and at a dilution of 1:500-1:1,000 using whole extrct of rat PC12 cells).

• Biochem/physiol Actions

  ER degradation-enhancing α-mannosidase-like 3 is an enzyme encoded by the EDEM3 gene in humans and consists of 931 amino acids. It consists of motifs of Class I α-mannosidases (glycosyl hydrolase family 47) in its N-terminal domain and a protease-associated motif in its C-terminal region. EDEM3 has α1,2-mannosidase activity. EDEM3 is also aasociated with folding-incompetent proteins carrying N-glycans that are extracted from futile folding cycles in the calnexin chaperone system.

Anti-ER degradation enhancer, mannosidase alpha-like 3 生産企業

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