ANTI-BECLIN 1 (N-TERMINAL) ウサギ宿主抗体

ANTI-BECLIN 1 (N-TERMINAL) ウサギ宿主抗体 価格

ANTI-BECLIN 1 (N-TERMINAL) ウサギ宿主抗体 化学特性,用途語,生産方法

• 使用

  Anti-Beclin 1 (N-terminal) antibody produced in rabbit has been used in:
  
  • immunofluorescent staining
  • immunoblotting
  • immunohistochemistry
  • immunoprecipitation
  
  

• 一般的な説明

  Beclin 1 (BECN1) or GT197 is a tumor suppressor gene. It is a Bcl-2 (B-cell lymphoma 2) interacting protein and is the mammalian ortholog of yeast Atg6/Vps30. It is a 450 amino-acid protein having three domains. The gene encoding BECN1 is localized on human chromosome 17q21.

• Biochem/physiol Actions

  Beclin 1 (BECN1) is able to complement the autophagy deficiency of yeast lacking autophagy-related gene 6 (Atg6) and restores autophagy in human MCF7 breast carcinoma cells. Beclin 1 plays a major role in the early development of embryo. It also serves as a haplo-insufficient tumor-suppressor gene. Heterozygous Beclin 1 mutant mice have increased spontaneous tumorigenesis. Beclin 1 is monoallelically deleted in a high percentage of sporadic human breast, ovarian and prostate carcinomas and is expressed at reduced levels in those tumors. In human brains BECN1 decreases in an age-dependent fashion, possibly leading to a reduction of autophagic activity during aging, which may contribute to the accumulation of mutant Huntingtin and the age-delayed disease onset of Huntington disease.

ANTI-BECLIN 1 (N-TERMINAL) ウサギ宿主抗体 生産企業

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