rel-(1R*,2S*)-2-フェニルシクロプロパン-1-アミン·塩酸塩

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

rel-(1R*,2S*)-2-フェニルシクロプロパン-1-アミン·塩酸塩 価格

rel-(1R*,2S*)-2-フェニルシクロプロパン-1-アミン·塩酸塩 化学特性,用途語,生産方法

• 化学的特性

  white to light beige powder or chunks

• 使用

  As with the MAO inhibitor drugs described above, tranylcypromine is also used for depressions that do not respond to other drugs.

• 一般的な説明

  A cell-permeable phenylcyclopropylamine that inhibits the monoamine oxidase and histone demethylase activities, respectively, of MAO A/B (K_i = 101.9 and 16.0 M, respectively) and LSD1/2 (K_i = 242.7 and 180.0 M, respectively), four members of a flavin-dependent amine oxidase family enzymes, by a covalent adduct formation with the enzyme-bound FAD. In addition to preventing LSD1-CoREST (Corepressor of RE1-Silencing Transcription factor) complex-mediated H3K4 demethylation (IC₅₀<2 M), TCP also inhibits LSD1-HCF-1 (Host Cell Factor-1) complex-mediated H3K9 demethylase activity, which is demonstrated to be an essential mechanism for the replication and latent infection of the α-herpesviruses HSV and VZV. The combined treatment of 2 M TCP and 10 M CHIR99061 is reported to enable the reprogramming of Oct4/Klf4-transduced primary HNEKs (Human Neonatal Epidermal Keratinocytes) into iPS (induced Pluripotent Stem) cells, albeit at a 100-time lower efficiency as seen in cultures transduced with 4-TFs (Oct44, Klf4, Sox2, and c-Myc).

• 生物活性

  Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO) (K i values are 242, 102 and 16 μ M for LSD1, MAO-A and MAO-B respectively). Inhibits histone demethylation.

rel-(1R*,2S*)-2-フェニルシクロプロパン-1-アミン·塩酸塩 生産企業

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rel-(1R*,2S*)-2-フェニルシクロプロパン-1-アミン·塩酸塩 スペクトルデータ(¹HNMR、FT-IR、IR、MS、Raman)

1986-47-6, rel-(1R*,2S*)-2-フェニルシクロプロパン-1-アミン·塩酸塩 キーワード