4-ベンジルピペリジン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

• 注意書き

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

4-ベンジルピペリジン 価格

4-ベンジルピペリジン 化学特性,用途語,生産方法

• 外観

  無色～うすい黄色透明液体

• 化学的特性

  clear colourless to yellow viscous liquid.

• 使用

  4-Benzylpiperidine was studied as acid corrosion inhibitor for iron. It was also used to study potential utility of dopamine-welective releaser as a treatment for cocaine dependence. In an assay of cocaine discrimination, 4-Benzylpiperidine had the most rapid onset and shortest duration of action.

• 製造方法

  4-Benzylpiperidine can be prepared by reacting 4-cyanopyridine with toluene. Catalytic hydrogenation of the pyridine ring then completes the synthesis.

• 主な応用

  Reactant for synthesis of:
  Antiproliferatives
  GABA uptake inhibitors
  Pyridines
  Histamine H3 antagonists
  Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer′s and neuronal vascular diseases
  Antiserotoninergic, antiplatelet, hemorheologic, antiarrythmic and antioxidant molecules via nucleophilic substitution

• 一般的な説明

  4-Benzylpiperidine is dopamine-selective releaser. It is a potential candidate for treatments for cocaine dependence.

• Biochem/physiol Actions

  4-Benzylpiperidine inhibits the activity of rat brain monoamine oxidase-A and -B, with IC50 values of 0.02 mM and 2 mM respectively. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an ec50 of 109/41.4/5246nM for DA/NE/5HT, respectively . It has a fast onset of action and a short duration. It also functions as a monoamine oxidase inhibitor (MAOI) with preference for MAO-A.

4-ベンジルピペリジン 上流と下流の製品情報

4-ベンジルピペリジン 生産企業

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4-ベンジルピペリジン スペクトルデータ(¹HNMR、¹³CNMR、IR1、MS、Raman)

31252-42-3, 4-ベンジルピペリジン キーワード