E 3330

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H411：長期的影響により水生生物に毒性

• 注意書き

  P273：環境への放出を避けること。

  P312：気分が悪い時は医師に連絡すること。

  P501：内容物/容器を．．．に廃棄すること。

E 3330 価格

E 3330 化学特性,用途語,生産方法

• 使用

  E 3330 is a potent and selective APE1 inhibitor used in the treatment for age related macular degeneration.

• Biochem/physiol Actions

  E3330 is a specific inhibitor of AP endonuclease 1 redox domain. E3330 inhibits APE-1 regulation of transcription factors, but does not affect Ape1 DNA repair activity. AP endonuclease 1 (APE1; also known as REF-1) is a multifunctional protein with dual functions in DNA repair and redox regulation of transcription factors. It is involved in apurinic/apyrimidinic endonuclease DNA base excision repair activity, in proofreading exonuclease activity, and in modulating DNA binding activity of several transcription factors including NF-κB, Egr-1, p53, AP-1, CREB, HIF-α, and members of the Pax family. APE1 is overexpressed in several human cancers, and disruption of APE1 function has detrimental effects on cancer cell viability. E3330 significantly reduces the growth of human pancreatic cancer cells in vitro and inhibits pancreatic cancer cell migration.

E 3330 生産企業

Global(57)Suppliers

E 3330 スペクトルデータ(¹HNMR)