CELECOXIB
化学名:CELECOXIB
CAS番号.184007-95-2
英語名:CELECOXIB
CBNumberCB91267649
MW0
MOL File184007-95-2.mol
CELECOXIB 化学特性,用途語,生産方法
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Originator
Celact,Sun Pharmaceuticals Industries Ltd.,India -
Manufacturing Process
4-(5-(4-Methylphenyl)-3-trifluoromethyl-N-pyrazol-1-yl)benzenesulfonamide To a solution of ethyl trifluoroacetate (1.90 ml, 16.0 mmol) in 7 ml of methyl tert-butyl ether was added 25% NaOMe (3.62 ml, 16.8 mmol). Next 4- chloroaceteophenone (2.08 ml, 16.0 mmol) in 2 ml of methyl tert-butyl ether was added. The mixture was stirred at room temperature overnight. To above solution was added 100 ml of 90% EtOH, followed by 4 N HCl (4.0 ml, 16 mmol) and 4-sulphonamidophenylhydrazine hydrochloride (3.58 g, 16 mmol). The mixture was heated to reflux for 3 hours. The mixture was concentrated. When 30 ml of water was added, a solid formed. The solid was filtered and washed with 20 ml of 60% EtOH to give 4.50 g of white solid. The filtrate was evaporated and taken up in ethyl acetate (100 ml), washed with saturated NaHCO3, and brine, dried over MgSO4, and concentrated. Heptane was added at boiling point of the mixture. After cooling down to 0°C, 1.01 g more product was obtained. The combined yield of the 4-(5-(4-methylphenyl)-3- trifluoromethyl-N-pyrazol-1-yl)benzenesulfonamide (Celecoxib) was 86%. -
Therapeutic Function
Antiinflammatory
CELECOXIB 生産企業
Global(13)Suppliers
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電話番号
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Hefei TNJ Chemical Industry Co.,Ltd.
電話番号 +86-0551-65418684<br/>+8618949823763
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Changzhou AniKare Pharmatech Co., Ltd.
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Credit Asia Chemical Co., Ltd.
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Nanjing crow LuNing pharmaceutical technology co., LTD
電話番号 13382066392
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Shanghai Han-Xiang Chemical Co., Ltd.
電話番号 15971444841
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Wuhan kemike Biomedical Technology Co., Ltd
電話番号 13163388153<br/>13163388153
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Zhongxin Chenshi (Wuhan) Technology Co., Ltd
電話番号 18942922096
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Hubei Hicks Biochemical Co., Ltd
電話番号 17362916295;<br/>17362916295
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