(R)-1-N-Boc-2-(hydroxymethyl)piperazine

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H332：吸入すると有害

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

(R)-1-N-Boc-2-(hydroxymethyl)piperazine 価格

(R)-1-N-Boc-2-(hydroxymethyl)piperazine 化学特性,用途語,生産方法

• 使用

  (R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate is used in preparation of novel substituted quinoline-8-carbonitrile derivatives with androgen receptor degradation activity and uses thereof.

• 合成

  Lithium aluminum hydride (1M in THF, 26 ml) was added to a solution of L-TERT- butyl 2-methyl (2R)-piperazine-1, 2-dicarboxylate (2. 55 g) in THF (70 ml) at-40°C, and then the reaction was warmed to room temperature. After stirring for 1 h, this reaction system was cooled to 0°C and quenched by sequential addition of water (1 ml), sodium hydroxide (2N, 1 ml), and then water (2 ml). The resulting slurry was filtered and concentrated in vacuo to give (R)-1-N-Boc-2-(hydroxymethyl)piperazine.
  

(R)-1-N-Boc-2-(hydroxymethyl)piperazine 上流と下流の製品情報

(R)-1-N-Boc-2-(hydroxymethyl)piperazine 生産企業

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(R)-1-N-Boc-2-(hydroxymethyl)piperazine スペクトルデータ(¹HNMR)

169448-87-7, (R)-1-N-Boc-2-(hydroxymethyl)piperazine キーワード