クロモグリク酸

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

クロモグリク酸 価格

MSDS Information

• 1,3-Bis(2-carboxychromon-5-yloxy)-2-hydroxypropane

クロモグリク酸 化学特性,用途語,生産方法

• 用途

  抗アレルギー薬肥満細胞安定化薬

• 効能

  抗アレルギー薬, 喘息治療薬, ケミカルメディエーター遊離抑制薬

• 説明

  Cromolyn is a synthetic analog of the plant extract khellin that was first developed in the late 1960s and introduced into clinical practice the following decade. It is continued to be used widely in the treatment of allergic rhinitis, asthma, mastocytosis, and conjunctivitis. It has an outstanding safety profile and can be readily obtained without prescription in many countries.

• 使用

  Anti Asthamatic

• 定義

  ChEBI: A dicarboxylic acid that is the bis-chromone derivative of glycerol. It is effective as a mast cell stabilizer.

• 一般的な説明

  Solid.

• 空気と水の反応

  Water soluble.

• 反応プロフィール

  Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Cromoglicic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat.

• 火災危険

  Flash point data for Cromoglicic acid are not available. Cromoglicic acid is probably combustible.

• 作用機序

  Cromolyn stabilizes the membranes of mast cells, stopping the release of allergy mediators and suppressing activation of eosinophiles, neutrophilis, thrombocytes, and macrophages, which take part in the formation of bronchospasms. Cromylyn differs from the majority of medications taken for obstructive diseases of the respiratory tract in that it is used only as a preventative agent.

• 臨床応用

  Cromolyn generally is used prophylactically for bronchial asthma (as an inhaled powder), for prevention of exercise-induced bronchospasm, and for seasonal and perennial allergic rhinitis (nasal solution). Topically, it also is used as eye drops for allergic conjunctivitis and keratitis. In the management of asthmatic conditions, it is administered using a power-operated nebulizer. The bioavailability is very low with oral administration because of poor absorption. By inhalation, the powder is irritating to some patients. After inhalation, much less than 10% of the dose reaches the systemic circulation. An oral dosage form is used for mastocytosis.

• 環境運命予測

  The major prophylactic effect of cromolyn is centered on inhibition of the degranulation of pulmonary mast cells causing a reduction in histamine release, reduced leukotriene production, and inhibition of release of inflammatory mediators from several cell types.

クロモグリク酸 上流と下流の製品情報

クロモグリク酸 生産企業

Global(122)Suppliers

16110-51-3, クロモグリク酸 キーワード