ブロモホルム

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H226：引火性の液体および蒸気

  H302：飲み込むと有害

  H314：重篤な皮膚の薬傷?眼の損傷

  H331：吸入すると有毒

  H411：長期的影響により水生生物に毒性

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P303+P361+P353：皮膚（または髪）に付着した場合：直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

ブロモホルム 価格

ブロモホルム 化学特性,用途語,生産方法

• 外観

  無色～わずかにうすい黄色, 澄明の液体

• 溶解性

  水に微溶 (0.1g/100ml水, 20℃), メタノール, エーテルに可溶。エタノール及びアセトンに極めて溶けやすく、水にほとんど溶けない。

• 解説

  ブロモホルム，トリブロモメタン(tribromomethane)ともいう．アセトンまたはエチルアルコールに次亜臭素酸塩を作用させるか，クロロホルムと臭化アルミニウムからつくる．無色の液体．融点7.8 ℃，沸点149.5 ℃．d¹⁵₄2.89．n¹⁵_D1.6005．エタノールなど有機溶媒に可溶，水に不溶．空気や光により徐々に分解して黄色になるので，冷暗所に密閉して貯蔵する．鉱物の浮遊試験(重液)や吸収麻酔薬に使われる．

• 用途

  難燃剤、ゲージ液、地質分析、重液選鉱、試薬

• 用途

  鉱物分析試薬、難燃剤

• 用途

  標準液調製用。

• 使用上の注意

  不活性ガス封入

• 化学的特性

  Bromoform is a colorless to pale yellow liquid with a high refractive index, very high density, and sweetish odor is similar to that of chloroform. It is slightly soluble in water and is nonflammable. Bromoform can form in drinking water as a by-product from the reaction of chlorine with dissolved organic matter and bromide ions.

• 物理的性質

  Clear, colorless to yellow liquid with a chloroform-like odor. Odor threshold concentration in water is 0.3 mg/kg (Verschueren, 1982).

• 定義

  ChEBI: Bromoform is a member of bromomethanes and a bromohydrocarbon.

• 主な応用

  In separating mixtures of minerals. Bromoform is used as a fluid for mineral ore separation in geological tests, as a laboratory reagent, and in the electronics industry in quality assurance programs.
  Bromoform was formerly used as a solvent for waxes, greases, and oils, as an ingredient in fire-resistant chemicals and in fluid gauges. It was also used in the early part of this century as a medicine to help children with whooping cough get to sleep. Currently, bromoform is only produced in small amounts for use in laboratories and in geological and electronics testing.

• 製造方法

  Bromoform can be prepared by reacting chloroform (see IAC, 1987) with aluminium tribromide at less th an or equal to 60°C; by reacting ethanol with sodium hypobromite; or by the redistribution reaction between chloroform and ethyl bromide (Harlow & Ross, 1932; Soroos & Hinkamp, 1945; Sherman & Kavasmaneck, 1980).

• 一般的な説明

  Bromoform appears as a colorless liquid with a chloroform-like odor. Denser than water (density: 2.9 g / cm3 ) and slightly soluble in water. Hence sinks in water. Nonflammable. Toxic by ingestion, inhalation and skin absorption. A lachrymator. Used as a solvent and to make pharmaceuticals. Often stabilized with 1 to 3% ethanol.

• 空気と水の反応

  Slightly soluble in water.

• 反応プロフィール

  Heating Bromoform to decomposition produces highly toxic fumes of carbon oxybromide (carbonyl bromide) and hydrogen bromide [Sax, 9th ed., 1996, p. 519]. Reaction with powdered potassium or sodium hydroxide, Li or Na/K alloys, is violently exothermic [Weizmann, C. et al., J. Am Chem. Soc., 1948, 70, p. 1189]. Explosive reaction with crown ethers in the presence of potassium hydroxide [Le Goaller, R. et al., Synth. Comm., 1982, 12, p. 1163].

• 危険性

  A questionable carcinogen. By ingestion, inhalation, and skin absorption. Liver damage, eye and upper respiratory tract irritant.

• 健康ハザード

  Probable routes of human exposure to bromoform are inhalation, ingestion, and dermal contact.
  Harmful if inhaled, swallowed, contacts skin or eyes or is absorbed through skin. It is a lachrymator, respiratory irritant, a narcotic and an hepatotoxin. Prolonged exposure may cause dermatitis. Inhalation causes irritation of nose and throat; provokes the flow of tears and saliva and reddening of the face. Ingestion may cause dizziness, disorientation and slurred speech, unconsciousness and death.
  Non-Cancer: Bromoform is a central nervous system depressant, and its vapors are highly irritating to the eyes and respiratory tract. Limited observations in humans and animal studies indicate that acute inhalation or oral exposure to high levels of bromoform may cause liver and kidney injury. Chronic effects of bromoform exposure in humans have not been studied, although animal studies indicate adverse effects on the liver, kidney, and central nervous system (U.S. EPA, 1994a).

• 火災危険

  Behavior in Fire: May decompose to produce toxic gases and vapor such as hydrogen bromide and bromine.

• 安全性プロファイル

  Suspected carcinogen with experimental neoplastigenic data. A human poison by ingestion. Moderately toxic by intraperitoneal and subcutaneous routes. Human mutation data reported. A lachrymator. It can damage the liver to a serious degree and cause death. It has anesthetic properties simdar to those of chloroform, but is not sufficiently volatile for inhalation purposes and is far too toxic for human use. As a sedative and antitussive its medicinal application has resulted in numerous poisonings. Inhalation of small amounts causes irritation, provoking the flow of tears and saliva, and reddening of the face. Abuse can lead to adhction and serious consequences. Explosive reaction with crown ethers or potassium hydroxide. Violent reaction with acetone or bases. Incompatible with Li or NaK alloys. When heated to decomposition it emits hghly toxic fumes of Br-. See also BROMIDES.

• 環境運命予測

  Biological. Bromoform showed significant degradation with gradual adaptation in a staticculture flask-screening test (settled domestic wastewater inoculum) conducted at 25 °C. At concentrations of 5 and 10 mg/L, percent losses after 4 wk of incubation were 48 and 35, respectively (Tabak et al., 1981).
  Surface Water. Kaczmar et al. (1984) estimated the volatilization half-life of bromoform from rivers and streams to be 65.6 d.
  Chemical/Physical. The estimated hydrolysis half-life in water at 25 °C and pH 7 is 686 yr (Mabey and Mill, 1978). Products of hydrolysis include carbon monoxide and hydrobromic acid (Kollig, 1993). When an aqueous solution containing bromoform was purged with hydrogen for 24 h, only 5% of the bromoform reacted to form methane and minor traces of ethane. In the presence of colloidal platinum catalyst, the reaction proceeded at a much faster rate forming the same end products (Wang et al., 1988). In an earlier study, water containing 2,000 ng/μL of bromoform and colloidal platinum catalyst was irradiated with UV light. After 20 h, about 50% of the bromoform had reacted. A duplicate experiment was performed but the concentration of bromoform was increased to 3,000 ng/μL and 0.1 g zinc was added. After 14 h, only 0.1 ng/μL bromoform remained. Anticipated transformation products include methane and bromide ions (Wang and Tan, 1988).
  At influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the adsorption capacities of the GAC used were 19.6, 5.9, 1.8, and 0.52 mg/g, respectively (Dobbs and Cohen, 1980).

• 合成方法

  アセトンやエタノールと次亜臭素酸塩との反応，またはクロロホルムと臭化アルミニウムとの反応により合成される

• 純化方法

  The storage and stability of bromoform and chloroform are similar. Ethanol, added as a stabilizer, is removed by washing with H2O or with saturated CaCl2 solution, and the CHBr3, after drying with CaCl2 or K2CO3, is fractionally distilled. Prior to distillation, CHBr3 has also been washed with conc H2SO4 until the acid layer is no longer coloured, then dilute NaOH or NaHCO3, and H2O. A further purification step is fractional crystallisation by partial freezing. [Beilstein 1 IV 82.]

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ブロモホルム スペクトルデータ(¹HNMR、¹³CNMR、IR1、MS、Raman)

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