N-ドコサノイルスフィンゴシン

N-ドコサノイルスフィンゴシン 化学特性,用途語,生産方法

• 解説

  N-アシルスフィンゴシンであり，スフィンゴシン塩基のアミノ基に脂肪酸がアミド結合している構造を有する．スフィンゴシン糖脂質，リン脂質としてまた遊離型で微生物，動植物に広く分布する．細胞へのさまざまな刺激で濃度が増大し，これが引き金となって細胞のアポトーシスを誘導することが知られている．

• 利点

  Ceramides are lipids, which are fatty acids that are produced in the sebaceous glands. Ceramides help to moisturise and strengthen the protective skin moisture barrier, and protect the skin from external aggressors such as weather and pollution.

• Mode of action

  Topically applied ceramide (Cer) could improve barrier function in three possible ways: (1) Cer in an appropriate formulation constructs (lamellar) liquid crystalline and/or gel structures; (2) Cer is likely incorporated into lamellar bilayer structures in the SC to repair incompetent bilayer structures; and/or (3) Cer penetrates into nucleated layers of the epidermis and becomes a precursor to endogenous Cer synthesis following hydrolysis to the sphingoid base and FA. In addition, Cer absorbed into nucleated layers of the epidermis could suppress KC proliferation and promote differentiation. Because Cer production is increased during KC differentiation, the stimulation of KC differentiation can increase de novo Cer production, thereby contributing to barrier formation[1].

N-ドコサノイルスフィンゴシン 生産企業

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