ベラプロストナトリウム

化学名:ベラプロストナトリウム

英語名:Beraprost sodium

CBNumberCB8761736

MFC24H29NaO5

MW420.47

别名

1-(3-ヒドロキシ-4-メチル-1-オクテン-6-イニル)-2-ヒドロキシ-2,3,3a,8b-テトラヒドロ-1H-シクロペンタ[b]ベンゾフラン-5-ブタン酸ナトリウム

2,3,3a,8b-テトラヒドロ-2-ヒドロキシ-1-(3-ヒドロキシ-4-メチル-1-オクテン-6-イニル)-1H-シクロペンタ[b]ベンゾフラン-5-ブタン酸ナトリウム

ベフラプロスト

ベラプロストナトリウム物理性質

融点	204-206°C
貯蔵温度	-20°C
溶解性	DMF:77.0(Max Conc. mg/mL);183.12(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);47.56(Max Conc. mM) PBS (pH 7.2):19.0(Max Conc. mg/mL);45.19(Max Conc. mM)
外見	粉
色	白からベージュ
InChIKey	YTCZZXIRLARSET-LIIFYGAANA-M
SMILES	[C@H]12[C@H](C[C@@H](O)[C@@H]1/C=C/[C@@H](O)C(C)CC#CC)OC1C(=CC=CC2=1)CCCC([O-])=O.[Na+] \|&1:0,1,3,5,8,r\|
CAS データベース	88475-69-8(CAS DataBase Reference)

危険有害性情報のコード(GHS)

効能
血圧降下薬, 血小板凝集抑制薬, プロスタグランジンI2受容体作動薬
商品名
ケアロード (東レ); ドルナー (東レ); プロサイリン (科研製薬); ベラサス (科研製薬)
説明
Beraprost sodium is a new, orally active antithrombotic epoprostenol analog introduced as a treatment for peripheral vascular disease, including Raynaud's syndrome and Buerger's disease. The antiplatelet activity may be due to its elevation of cyclic AMP in platelets which is achieved by activating adenylate cyclase in the platelet membrane, followed by the inhibition ofCa⁺⁺- influx and thromboxane A2 formation.
化学的特性
White Solid
使用
Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).
一般的な説明
Beraprost sodium is an orally active prostacyclin analog.
副作用
Disease-related events had similar incidence in patients receiving beraprost and those receiving placebo. Drug-related adverse events like headache, flushing, jaw pain, and diarrhea were more common in patients treated with beraprost sodium and occurred mostly during the six-week titration period. The incidence was markedly reduced in the maintenance period. Six patients (9%) in the beraprost sodium group and two (3%) in the placebo group withdrew prematurely from the study because of adverse events. No clinically adverse changes in hematologic or biochemical variables were seen in the beraprost sodium group.