トカイニド塩酸塩

トカイニド塩酸塩 価格

トカイニド塩酸塩 化学特性,用途語,生産方法

• 効能

  抗不整脈薬, ナトリウムチャネル遮断薬

• 使用

  Tonocard(AstraZeneca).

• 一般的な説明

  Tocainide hydrochloride,2-amino-2＇ ,6 ＇-propionoxyxylidide hydrochloride (Tonocard)(pKa 7.7), is an analog of lidocaine. It is orally active and haselectrophysiological properties like those of lidocaine. Totalbody clearance of tocainide hydrochloride is only166 mL/min, suggesting that hepatic clearance is not large.Because of low hepatic clearance, the hepatic extraction ratiomust be small; therefore, tocainide hydrochloride is unlikelyto be subject to a substantial first-pass effect. The drug differsfrom lidocaine, in that it lacks two ethyl groups, which providestocainide hydrochloride some protection from first-passhepatic elimination after oral ingestion. Tocainide hydrochlorideis hydrolyzed in a manner similar to that of lidocaine.None of its metabolites is active.

• 臨床応用

  Tocainide hydrochloride is classed as a IB antiarrhythmicagent and used orally to prevent or treat ventricular ectopyand tachycardia. The drug is given in 400- to 600-mgdoses every 8 hours.

トカイニド塩酸塩 生産企業

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35891-93-1, トカイニド塩酸塩 キーワード