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3,4-メチレンジオキシ-8-メトキシ-10-ニトロフェナントレン-1-カルボン酸

3,4-メチレンジオキシ-8-メトキシ-10-ニトロフェナントレン-1-カルボン酸 化学構造式
313-67-7
  • CAS番号.313-67-7
  • 化学名:3,4-メチレンジオキシ-8-メトキシ-10-ニトロフェナントレン-1-カルボン酸
  • 别名:6-ニトロ-8-メトキシフェナントロ[3,4-d]-1,3-ジオキソール-5-カルボン酸;8-メトキシ-6-ニトロフェナントロ[3,4-d]-1,3-ジオキソール-5-カルボン酸;アリストロク酸I;8-メトキシ-10-ニトロ-3,4-(エポキシメタノキシ)フェナントレン-1-カルボン酸;アリストロキン酸;3,4-メチレンジオキシ-8-メトキシ-10-ニトロフェナントレン-1-カルボン酸;アリストロキア酸;アリストロク酸A;アリストロキン酸I;アリストロク酸;アストロキン酸;アリストロキン酸A;アリストロチク酸A
  • 英語化学名:Aristolochic acid
  • 英語别名:TR 1736;tardolyt;nsc-50413;NSC 11926;birthwort;Descresept;Aristolochic;aristolochin;aristolochine;Aristolochia A
  • CBNumber:CB8481548
  • Molecular Formula:C17H11NO7
  • Formula Weight:341.27
  • MOL File:313-67-7.mol
3,4-メチレンジオキシ-8-メトキシ-10-ニトロフェナントレン-1-カルボン酸 物理性質
  • 融点  :260 °C
  • 沸点  :476.92°C (rough estimate)
  • 比重(密度)  :1.3162 (rough estimate)
  • 屈折率  :1.4500 (estimate)
  • 貯蔵温度  :2-8°C
  • 溶解性 :DMSO: soluble
  • 外見  :powder
  • 酸解離定数(Pka) :2.99±0.20(Predicted)
  • 色 :yellow
  • InChIKey :LIDQMWRBMLSXLL-UHFFFAOYSA-N
  • CAS データベース :313-67-7(CAS DataBase Reference)
  • IARC :1 (Vol. 82, 100A) 2012, 1 (Vol. 82, 100A) 2012
安全性情報
  • 主な危険性  :T
  • Rフレーズ  :25-68-36/37/38-23/24/25-45
  • Sフレーズ  :7-35-45-36/37/39-26-53
  • RIDADR  :UN 1544 6.1/PG 3
  • WGK Germany  :3
  • RTECS 番号 :CF3325000
  • 国連危険物分類  :6.1(b)
  • 容器等級  :III
  • HSコード  :29329990
  • 毒性 :LD50 in male, female mice, male, female rats (mg/kg): 38.4, 70.1, 82.5, 74.0 i.v.; 55.9, 106.1, 203.4, 183.9 orally (Mengs)
危険有害性情報のコード(GHS)
  • 絵表示(GHS)
  • 注意喚起語Danger
  • 危険有害性情報
  • H301:飲み込むと有毒
  • H351:発がんのおそれの疑い
  • 注意書き
  • P280:保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
3,4-メチレンジオキシ-8-メトキシ-10-ニトロフェナントレン-1-カルボン酸 価格 もっと(16)
  • メーカー: 富士フイルム和光純薬株式会社(wako)
  • 製品番号: W01CHDASB-00011000
  • 製品説明 : アリストロキン酸
  • 純度: Aristolochic Acid
  • 包装: 25mg
  • 価格: ¥15000
  • 更新時間: 2020/09/21
  • 購入: 購入
  • メーカー: 富士フイルム和光純薬株式会社(wako)
  • 製品番号: W01CHDASB-00011002
  • 製品説明 : アリストロキン酸A
  • 純度: Aristolochic Acid A
  • 包装: 5mg
  • 価格: ¥71600
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 関東化学株式会社(KANTO)
  • 製品番号: 49870-55
  • 製品説明 : アリストロキン酸
  • 純度: Aristolochic acid
  • 包装: 10mg
  • 価格: ¥43000
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 関東化学株式会社(KANTO)
  • 製品番号: 22609-1A
  • 製品説明 : アリストロキン酸
  • 純度: Aristolochic acid
  • 包装: 100mg
  • 価格: ¥23500
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: Sigma-Aldrich Japan
  • 製品番号: Y0001185
  • 製品説明 : 
  • 純度: Aristolochic acid IEuropean Pharmacopoeia (EP) Reference Standard
  • 包装: 
  • 価格: ¥35200
  • 更新時間: 2021/03/23
  • 購入: 購入

3,4-メチレンジオキシ-8-メトキシ-10-ニトロフェナントレン-1-カルボン酸 MSDS


8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid

Aristolochic acid 化学特性,用途語,生産方法

  • 説明 Aristolochic acid first appeared in Chinese medicine in the fifth century AD, while it was used to treat kidney and urinary diseases, as well as gout, snakebites, and a variety of other ailments. In many of these cases, aristolochic acid was just one of the main components of the salves. In the first century, aristolochic acid was first described as a composition of ingested medicine to treat symptoms such as asthma, hiccups, pains, and spasms.
  • 化学的特性 Shiny brown leaflets or a yellow or white powder.
  • 物理的性質 Appearance: brown sheet crystal or yellow powder. Solubility: practically insoluble in water and soluble in ethanol, chloroform, ethyl ether, acetone, glacial acetic acid, and aniline. Melting point: 260–265?°C (500–509?°F; 533–538?K).
  • 来歴 At a clinic in Brussels, Belgium, a group of women who had all taken the same weight loss supplement, Aristolochia fangchi, which contained aristolochic acid, was first diagnosed with aristolochic acid poisoning. Balkan endemic nephropathy (BEN) was later found to be also the result of aristolochic acid (AA) consumption. Balkan endemic nephropathy is likely caused by low-level AA exposure, possibly from the contamination of wheat flour seeds by Aristolochia clematitis. BEN falls under the umbrella of what is now known as aristolochic acid nephropathy, the prevalent symptom of AA poisoning .
  • 使用 PLA2 inhibitor
  • 使用 Aristolochic acids occur in Aristolochiaceae and in butterflies feeding on these plants. One of a group of fourteen known, substituted 1-phenanthrenecarboxylic acids
  • 定義 ChEBI: A monocarboxylic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is b th carcinogenic and nephrotoxic.
  • 適応症 Due to the widely associated kidney problems and urothelial cancers, the FDA has issued warnings regarding consumption of AA-containing supplements.
  • brand name Acidum aristolchicum;Descresepet;Fago-araxin;Fluocinova;Predno-facilus haemota.
  • 世界保健機関(WHO) Extracts of aristolochiaceae have traditionally been used as a bitter for which a broad range of therapeutic effects has been claimed. Aristolochic acid is claimed to promote phagocytosis and to have immunostimulant activity. However, in 1981, a three-month toxicity study in rats revealed the carcinogenic potential of aristolochic acid and preparations containing this substance have since been withdrawn in several countries.
  • 薬理学 In 1992, some cases of women present with a rapidly progressive renal failure after having a slimming regimen including powdered extracts of Chinese herbal preparations. This outbreak of renal failure eventually resulted in about 100 cases in 1998, 70% of them being in end-stage renal disease (ESRD) . Recent research has confirmed that the main reason leading to renal injury is aristolochic acid found in many Chinese herbs . Aristolochic acid, a potent human carcinogen from Aristolochia plants, is associated with the incidence of urothelial carcinoma in the upper urinary tract (UUC). After the metabolic activation, aristolochic acid reacted with DNA to form aristolactam (AL)-DNA adducts. Mainly pathological changes are in renal cortex, where they serve as a specific biomarker, and are also found in urothelium, where they lead to a unique mutational signature in the TP53 tumorsuppressor gene. The conclusion is that exposure to aristolochic acid gives rise to the incidence of UUC, a finding with significant implications for the global public health .
  • 臨床応用 Aristolochia species are nephrotoxic and carcinogenic, and FDA has issued warnings regarding consumption of AA-containing supplements.
  • 安全性プロファイル Confirmed carcinogen. Poison by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NO,. Potentially Toxic Chemicals: April 1982." Vol. 5 No. 1: The Ministry of Health of the Federal Republic of Germany has withdrawn from the national market drugs containing aristolochic acid. The decision resulted from the demonstration of a carcinogenic potential in a three-month ingestion toxicity study undertaken in rats. Aristolochic acid is claimed to promote phagocytosis and to have immunostimulant activity. A growth-inhibiting effect on experimentally induced tumors has been described, but this effect has not been shown to have any clinical relevance. Extracts of species of Aristolochiacea have tradtionally been used as a bitter, and a broad range of therapeutic effects has been claimed.
  • 職業ばく露 Aristolochic acids are alkaloids used primarily as a chemical intermediate for pharmaceuticals, lab chemicals, herbal extract, drug.
  • 輸送方法 UN1544 Alkaloids, solid, n.o.s. or Alkaloid salts, solid, n.o.s. poisonous, Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required. PG III.
  • 不和合性 Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
  • 廃棄物の処理 It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. All federal, state, and local environmental regulations must be observed.
3,4-メチレンジオキシ-8-メトキシ-10-ニトロフェナントレン-1-カルボン酸 上流と下流の製品情報
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313-67-7, 3,4-メチレンジオキシ-8-メトキシ-10-ニトロフェナントレン-1-カルボン酸 キーワード:
  • 313-67-7
  • Aristolochic acid Ⅰ
  • nsc-50413
  • tardolyt
  • 8-METHOXY-6-NITROPHENANTHROL(3,4-D)-1,3-DIOXIDE-5-CARBOXYLIC ACID
  • ARISTOLOCHIC ACID
  • ARISTOLOCHIC ACID A
  • ARISTOLOCHIC ACID I
  • Aristolochic acid, mixture of I and II, 96%
  • 8-Methoxy-6-nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic Acid
  • Aristolochia A
  • Aristolochic Acid 1
  • NSC 11926
  • TR 1736
  • Aristolochic
  • Aristolochic acid (93% of Aristolochic acid I)
  • 8-methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid
  • ARISTOLOCHIC ACID FREE ACID
  • ARISTOLOCHICACIDSALTS
  • Aristolochic acid Ⅲ
  • Aristolochic acid I,TR 1736
  • Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro-
  • Aristolochic acid, 96%, mixture of i and ii
  • Aristolochic Acid,from Aristolochiaceae
  • ARISTOLOCHIC ACID A(P)
  • 3,4-methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylicacid
  • 4-d)-1,3-dioxole-5-carboxylicacid,8-methoxy-6-nitro-phenanthro(
  • 8-methoxy-6-nitrophenanthol(3,4-d)1,3-dioxole-5-carboxylicacid
  • aristolochin
  • aristolochine
  • birthwort
  • 6-ニトロ-8-メトキシフェナントロ[3,4-d]-1,3-ジオキソール-5-カルボン酸
  • 8-メトキシ-6-ニトロフェナントロ[3,4-d]-1,3-ジオキソール-5-カルボン酸
  • アリストロク酸I
  • 8-メトキシ-10-ニトロ-3,4-(エポキシメタノキシ)フェナントレン-1-カルボン酸
  • アリストロキン酸
  • 3,4-メチレンジオキシ-8-メトキシ-10-ニトロフェナントレン-1-カルボン酸
  • アリストロキア酸
  • アリストロク酸A
  • アリストロキン酸I
  • アリストロク酸
  • アストロキン酸
  • アリストロキン酸A
  • アリストロチク酸A