ゲルダナマイシン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H227：引火性液体

  H303：飲み込むと有害のおそれ

• 注意書き

  P403+P235：換気の良い場所で保管すること。涼しいところに 置くこと。

ゲルダナマイシン 価格

ゲルダナマイシン 化学特性,用途語,生産方法

• 外観

  結晶～粉末

• 溶解性

  メタノールに溶ける。

• 用途

  抗腫瘍性抗生物質です。ベ ンゾキノイド 骨 格 を 有 し、HSP90（Heat Shock Protein 90）の ATP 結合部位に結合 することで HSP90 の機能阻害作用を示しま す。

• 用途

  薬理研究用。

• 説明

  Geldanamycin from Streptomyces hygroscopicus.
  Geldanamycin is a benzoquinone ansamycin antitumor antibiotic. Geldanamycin binds specifically to Hsp90 (Heat Shock Protein 90) and to its endoplasmic reticulum homologue GP96. The Hsp90 chaperone is required for the activation of several families of eukaryotic protein kinases and nuclear hormone receptors, many of which are proto-oncogenic and play a prominent role in cancer. The geldanamycin antibiotic has antiproliferative and antitumor effects, as it binds to Hsp90, inhibits the Hsp90-mediated conformational maturation/refolding reaction, and results in the degradation of Hsp90 substrates. Hsp90 also plays a key role in regulating the physiology of cells exposed to environmental stress and thus, geldanamycin interferes with cellular stress response.
  Geldanamycin was found to be a potent antibiotic active at nanomolar concentrations against 60 cell lines as well as in mouse tumor models.
  It is an inhibitor of proto-oncogenic protein kinases, such as erbB22, EFG receptor tyrosine kinases, and non-receptor tyrosine kinases, such as v-src and Raf-1. In addition, it is a potent inhibitor of the nuclear hormone receptor family including the estrogen and androgen hormone receptors.

• 化学的特性

  Yellow to Orange Powder

• 使用

  Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

• 定義

  ChEBI: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.

• 一般的な説明

  Chemical structure: benzenoid

• 生物活性

  Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (K d = 1.2 μ M) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors.

ゲルダナマイシン 上流と下流の製品情報

ゲルダナマイシン 生産企業

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ゲルダナマイシン スペクトルデータ(MS)

30562-34-6, ゲルダナマイシン キーワード