3-アミノ-5-[(ヘキサヒドロ-1H-アゼピン)-1-イル]-6-クロロ-N-(アミノイミノメチル)-2-ピラジンカルボアミド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

3-アミノ-5-[(ヘキサヒドロ-1H-アゼピン)-1-イル]-6-クロロ-N-(アミノイミノメチル)-2-ピラジンカルボアミド 価格

3-アミノ-5-[(ヘキサヒドロ-1H-アゼピン)-1-イル]-6-クロロ-N-(アミノイミノメチル)-2-ピラジンカルボアミド 化学特性,用途語,生産方法

• 説明

  5-(N,N-hexamethylene)-Amiloride (HMA) is a derivative of amiloride with diverse biological activities. It is an allosteric antagonist of adenosine A_2A receptors (K_i = 3.3 μM). HMA inhibits the cation-selective ion channel formed by the HIV-1 viral protein Vpu when used at a concentration of 50 μM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu when used at a concentration of 10 μM. It also blocks the cation-selective ion channels formed by the hepatitis C virus (HCV) protein p7. HMA (40 μM) induces necrosis in and reduces the viability of MCF-7, MDA-MB-231, T47D, SK-BR-3, Met-1, and NDL breast cancer cells but not cardiomyocytes or uterine, pulmonary, and renal epithelial cells. HMA protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls.

• 定義

  ChEBI: A member of the class of pyrazines that is amiloride in which the two amino hydrogens at position N-5 are replaced by a hexamethylene moiety, resulting in the formation of an azepane ring.

• Biochem/physiol Actions

  Inhibitor of Na+/H+ antiport.

3-アミノ-5-[(ヘキサヒドロ-1H-アゼピン)-1-イル]-6-クロロ-N-(アミノイミノメチル)-2-ピラジンカルボアミド 生産企業

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