3,5,7-トリヒドロキシフラボン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

3,5,7-トリヒドロキシフラボン 価格

3,5,7-トリヒドロキシフラボン 化学特性,用途語,生産方法

• 効能

  別名：ガランギン (galangin)；淡黄色；再結 エタノール；トリアセタート〔mp. 142～143.5 °C〕

• 説明

  Galangin is a flavonoid naturally found in herbs used in traditional medicine. Like many flavonoids, it has potent antioxidant properties. It also has anti-inflammatory actions related to suppression of signaling through NF-κB in mice. Galangin acts as an antagonist of the aryl hydrocarbon receptor, inducing apoptosis in cancer cells. It also inhibits cytochrome P450 isoform 1A1 with an IC₅₀ value of less than 1 μM.

• 化学的特性

  Yellow powder

• 定義

  ChEBI: A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively.

• 一般的な説明

  Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.

• 抗がん研究

  Galangin is a flavonol that is derived from Alpinia officinarum, a plant from the gingerfamily, grown in Southeast Asia. The extract from the rhizome suppresses cellproliferation of hepatocellular carcinoma cells (Su et al. 2013). ER stress is inducedby galangin as is evident by rise in concentration of cytosolic Ca2+ and other UPRtarget genes like CHOP, GRP 78 and GRP 94. The ER is a major storage site forintracellular calcium. Normal functioning of ER chaperones is disrupted by calciumexhaustion in ER which produces ER stress and hence activation of UPR (Hotamisligil2010; Mekahli et al. 2011). CHOP and 4-polybutyric acid siRNA, well-known ERstress inhibitor, substantially blocked stress induced by galangin in the HCC cell line.To sum up, ER stress is upregulated by galangin, inhibiting cancer cell proliferation,and galangin can prove to be an effective anticancer agent (Su et al. 2013).

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