モノクローナル抗ヒストンH3, リン酸化型(PSER28)抗体 ラット宿主抗体

モノクローナル抗ヒストンH3, リン酸化型(PSER28)抗体 ラット宿主抗体 価格

モノクローナル抗ヒストンH3, リン酸化型(PSER28)抗体 ラット宿主抗体 化学特性,用途語,生産方法

• 使用

  Monoclonal Anti-phospho-Histone H3 (pSer28) antibody is suitable for immunoblotting (approx. 15 kDa), immunocytochemistry (3.7% formaldehyde-methanol fixation) and flow cytometry applications.

• 一般的な説明

  Histone H1 and the N-terminal tail of histone-3 (H3) have key roles in the folding and inter-association of the chromatin fibers. Two currently known phosphorylation sites are present in the N-terminus of H3; serine-10 and serine-28. Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A). Histone H3 is located on human chromosome 6p22.

• Biochem/physiol Actions

  Mitogenic stimulation, oncogenic transformation, or induction of oncogenic ras expression are accompanied with increase in serine-10 phosphorylation of the H3 N-terminal domain. It has been shown that phosphorylated H3 is associated with c-fos and c-myc genes in stimulated cells. Phosphorylation of H3, at both serine-10 and -28, coincides with the induction of mitotic chromosome condensation.H3 phosphorylation may contribute to proto-oncogene induction by modulating chromatin structure and releasing blocks in elongation. H3 dephosphorylation occurs quite rapidly after mitosis and serine-10/28 reo main unphosphorylated throughout the remainder of interphase. PP1 has been identified as the H3 phosphatase.

モノクローナル抗ヒストンH3, リン酸化型(PSER28)抗体 ラット宿主抗体 生産企業

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