6H-INDENO[1,2-E]TETRAZOLO[1,5-B][1,2,4]TRIAZIN-6-ONE

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P330：口をすすぐこと。

  P501：内容物/容器を．．．に廃棄すること。

6H-INDENO[1,2-E]TETRAZOLO[1,5-B][1,2,4]TRIAZIN-6-ONE 価格

6H-INDENO[1,2-E]TETRAZOLO[1,5-B][1,2,4]TRIAZIN-6-ONE 化学特性,用途語,生産方法

• 説明

  KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. By blocking Akt signaling, KP372-1 has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells with an IC₅₀ value of 30-60 nM in vitro. In acute myelogenous leukemia cells, KP372-1 is reported to inhibit the kinase activity of Akt, PDK1, and FLT3, decreasing the colony-forming ability of these cells with an IC₅₀ value less than 200 nM.

• 使用

  KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. By blocking Akt signaling, KP372-1 has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells.

6H-INDENO[1,2-E]TETRAZOLO[1,5-B][1,2,4]TRIAZIN-6-ONE 生産企業

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