1-メチル-4-フェニル-1,2,5,6-テトラヒドロピリジン
化学名:1-メチル-4-フェニル-1,2,5,6-テトラヒドロピリジン
CAS番号.28289-54-5
英語名:1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
CBNumberCB8254906
MFC12H15N
MW173.25
MOL File28289-54-5.mol
别名
1,2,5,6-テトラヒドロ-1-メチル-4-フェニルピリジン
1-メチル-4-フェニル-1,2,3,6-テトラヒドロピリジン
4-フェニル-1-メチル-1,2,5,6-テトラヒドロピリジン
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1-メチル-4-フェニル-1,2,5,6-テトラヒドロピリジン物理性質
| 融点 | aprox. 36°C |
| 沸点 | 128-132 °C12 mm Hg(lit.) |
| 比重(密度) | 1.001±0.06 g/cm3(Predicted) |
| 貯蔵温度 | Inert atmosphere,Room Temperature |
| 溶解性 | Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly) |
| 外見 | Solid |
| 酸解離定数(Pka) | 8.66±0.40(Predicted) |
| 色 | Pale Yellow to Light Yellow |
| Merck | 13,6319 |
| 安定性： | 安定。強力な酸化剤とは相容れない。 |
| 主な危険性 | T |
| Rフレーズ | 25-39/23/24/25 |
| Sフレーズ | 45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS 番号 | UT8358900 |
| 国連危険物分類 | 6.1(b) |
| 容器等級 | III |
| 有毒物質データの | 28289-54-5(Hazardous Substances Data) |
| 毒性 | Human toxicity originally discovered when it was an unexpected by-product from the illicit synthesis of a heroin substitute (i.e., meperidine analog). Currently used experimentally as the primary animal model for the study of Parkinson’s disease. MPTP is a neurotoxicant that is activated to 1-methyl-4-phenylpyridinium ion (MPP1) by the actions of monoamine oxidase B located in the mitochondria of brain astrocytes. The MPP1 is then transported into dopamine, and to a lesser extent, other monoaminergic neurons. Once inside these dopamine neurons in the substantia nigra, it destroys these neurons by mechanisms that may involve an oxidative cascade and/or inhibition of electron transport. Intoxication causes a parkinsonism syndrome almost identical in signs and symptoms to Parkinson’s disease, including rigidity, bradykinesia, tremor, and postural instability. In the event of known ingestion, immediate (but not delayed) administration of a monoamine oxidase inhibitor (especially one selective for MAO-B like deprenyl) and dopamine uptake inhibitor can be therapeutic. |
