Unii-0Bz5A00fqu

Unii-0Bz5A00fqu 化学特性,用途語,生産方法

• 化学的特性

  Polacrilin potassium occurs as a cream-colored, odorless and tasteless, free-flowing powder. Aqueous dispersions have a bitter taste.

• 使用

  Pharmaceutic aid (tablet disintegrant).

• 調製方法

  Polacrilin resin (Amberlite IRP-64) is prepared by the copolymerization of methacrylic acid with divinylbenzene (DVB). Polacrilin potassium (Amberlite IRP-88) is then produced by neutralizing this resin with potassium hydroxide.
  Other resins are similarly produced by copolymerization between styrene and divinylbenzene (Amberlite IRP-69, Amberlite IRP-67, Amberlite IR-120, and Amberlite IRA-400). Phenolicbased polyamine condensates (Amberlite IRP-58) may also be produced.
  The homogeneity of the resin structure depends on the purity, nature, and properties of the copolymers used as well as the controls and conditions employed during the polymerization reaction. The nature and degree of crosslinking have significant influence on the physicochemical properties of the resin matrix. The functional groups introduced on the matrix confer the property of ion exchange. Depending upon the acidity or basicity of the functional groups, strongly acidic to strongly basic types of ion-exchange resins may be produced.

• 応用例（製薬）

  Polacrilin potassium is a cation-exchange resin used in oral pharmaceutical formulations as a tablet disintegrant Concen-trations of 2–10% w/w have been used for this purpose, although 2% w/w of polacrilin potassium is usually sufficient. Other polacrilin ion-exchange resins have been used as excipients to stabilize drugs, to mask or modify the taste of drugs, and in the preparation of sustained-release dosage forms and drug carriers.
  Polacrilin resins are also used in the analysis and manufacture of pharmaceuticals and food products.

• 安全性

  Polacrilin potassium and other polacrilin resins are used in oral pharmaceutical formulations and are generally regarded as nontoxic and nonirritant materials. However, excessive ingestion of polacrilin resins may disturb the electrolyte balance of the body.

• 貯蔵

  Polacrilin potassium and other polacrilin resins are stable to light, air, and heat up to their maximum operation temperature. Excessive heating can cause thermal decomposition of the resins and may yield one or more oxides of carbon, nitrogen, sulfur, and/or amines.
  Polacrilin resins should be stored in well-closed containers in a cool, dry place.

• 不和合性

  Incompatible with strong oxidizing agents, amines, particularly tertiary amines, and some other substances that interact with polacrilin resins.

• 規制状況(Regulatory Status)

  Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in non-parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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