2-(Hydroxymethyl)isonicotinic acid

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

2-(Hydroxymethyl)isonicotinic acid 化学特性,用途語,生産方法

• 合成

  Ethyl 2-(hydroxymethyl)isonicotinate (iso-EhmnH) (4.84 g, 26.7 mmol) was dissolved in THF/H2O (40 mL, v:v = 1:1). KOH (4.58 g, 81.6 mmol, 3 eq.) was added as solid and the mixture stirred at 100 °C for 20 h and then cooled to r.t. The mixture was further cooled in ice-water and then HNO3 added to adjust the pH to 4–5. The solvent was removed under vacuum. The organic part in the solid mixture was then extracted twice with 400 mL of ethanol and the solvent removed. The powder contains inorganic material was added in hot isopropanol and then filtered, evaporation of iso-propanol yielded iso-hmnH2 as white powder. Yield 2.93 g, 72%[1].
  

2-(Hydroxymethyl)isonicotinic acid 生産企業

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