Anti-TERF2-Interacting Protein, Anti-TERF2IP

Anti-TERF2-Interacting Protein, Anti-TERF2IP 価格

Anti-TERF2-Interacting Protein, Anti-TERF2IP 化学特性,用途語,生産方法

• 使用

  Monoclonal Anti-RAP1 antibody produced in mouse may be used in enzyme linked immunosorbent assay (ELISA) and immunoblotting.

• 一般的な説明

  Monoclonal Anti-RAP1 (mouse IgG2b isotype) is derived from the hybridoma 4C8/1 produced by the fusion of mouse myeloma cells (Sp2/0 Ag.14 cells) and splenocytes from BALB/c mice immunized with human RAP1. Ras-related protein 1 (RAP1) protein contains 399 amino acids with an acidic C-terminus featuring a 33 amino acid coiled-coil region and a bipartite nuclear localization signal. It is expressed ubiquitously, is located at telomeres and affects telomer length.

• Biochem/physiol Actions

  Rap1 (repressor/activator protein) helps to guard telomeres, assemble telomerase, and controls telomere length. At telomeres, Rap1 also participates in the suppression of non-homologous end joining (NHEJ). It involves in genomewide transcriptional modulation. Knockdown of Rap1 induces apoptosis in hepatocellular carcinoma cell line HepG2.

Anti-TERF2-Interacting Protein, Anti-TERF2IP 生産企業

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