アデノシン-5'-ペンタホスファートε-5'-アデノシルα,β,γ,δ,ε-ペンタナトリウム

アデノシン-5'-ペンタホスファートε-5'-アデノシルα,β,γ,δ,ε-ペンタナトリウム 価格

アデノシン-5'-ペンタホスファートε-5'-アデノシルα,β,γ,δ,ε-ペンタナトリウム 化学特性,用途語,生産方法

• 使用

  P¹,P⁵-Di(adenosine-5′) pentaphosphate pentasodium salt has been used as:
  
  • an adenylate kinase (AK) inhibitor in: sarcoma osteogenic (Saos-2) cells
  • mitochondrial lysates during ATP synthesis
  • tetramethylrhodamine methyl ester (TMRM) based membrane potential assay
  • chromoplasts
  
  

• 一般的な説明

  P¹,P⁵-Di(adenosine-5′) pentaphosphate (Ap5A) is a diadenosine polyphosphate, which has a tail-to-tail dimer structure. Ap5A is synthesized in a twostep process involving the formation of adenosine 5′-tetraphosphate (P4A) from the ATP and trimeta-phosphate (P3). In the second step, P4A is converted to Ap5A. The synthesis of Ap5A requires a pH optimum in the range of 7.5 to 8.5 and is modulated by metal ions.

• Biochem/physiol Actions

  A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.

アデノシン-5'-ペンタホスファートε-5'-アデノシルα,β,γ,δ,ε-ペンタナトリウム 生産企業

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