スルファドキシン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H317：アレルギー性皮膚反応を起こすおそれ

  H411：長期的影響により水生生物に毒性

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P272：汚染された作業衣は作業場から出さないこと。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P333+P313：皮膚刺激または発疹が生じた場合：医師の診断/手当てを 受けること。

スルファドキシン 価格

MSDS Information

• Sulformethoxine

スルファドキシン 化学特性,用途語,生産方法

• 外観

  白色, 結晶性粉末〜粉末

• 溶解性

  アセトンに溶け、水及びエタノールにほとんど溶けない。

• 用途

  高速液体クロマトグラフ法によるスルファドキシン定量用標準品。

• 効能

  抗菌薬, 抗マラリア薬, 葉酸合成阻害薬

• 説明

  Sulfadoxin is a sulfonamide antibiotic that inhibits dihydropteroate synthetase (DHPS), an enzyme involved in folic acid synthesis. Sulfadoxin competes with 4-aminobenzoate (PABA), the native substrate of DHPS, and inhibits PABA incorporation into folic acid. Folate is essential for purine and pyrimidine synthesis, therefore, sulfadoxin has antiproliferative activity in non-resistant P. falciparum. Sulfadoxin inhibits growth of P. falciparum in vitro, but potency varies between non-resistant (IC₅₀ = 4 ng/ml) and resistant strains (IC₅₀ = 3,970 ng/ml).

• 化学的特性

  White Crystalline Solid

• 定義

  ChEBI: A sulfonamide consisting of pyrimidine having methoxy substituents at the 5- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position. In combination with the antiprotozoal pyrimethamine (CHEBI:8673) it is used as an antimalarial.

• 抗菌性

  Its antibacterial activity is relatively poor. Used alone it has a slow and uncertain effect against malaria parasites. Resistance of malaria parasites to the combination with pyrimethamine is common in many endemic areas.

• 応用例（製薬）

  An ultra-long-acting sulfonamide. It is no longer prescribed alone, but is used in combination with pyrimethamine as the antimalarial agent Fansidar. It is poorly soluble in water.

• 薬理学

  In terms of antibacterial action, this drug is analogous to other sulfanilamides; however, it possesses very prolonged action. Its half-life is from 120 to 200 h. Sulfadoxine is used for infectious diseases caused by microorganisms that are sensitive to the sulfanilamide drugs, such as infections of respiratory organs, gastric and urinary tracts; purulent infections of various localization, osteomyelitis, sinusitis, and other infections. It is used in combination with antimalarial drugs. Synonyms of this drug are sulfarmethoxine, fanasil, and fansidar.

• 薬物動態学

  Oral absorption ：Extensive
  C_max 500 mg oral： c. 60 mg/L after 3–4 h
  Plasma half-life：c.6 days
  Volume of distribution：0.13 L/kg
  Plasma protein binding：94%
  The extremely long half-life allows administration at weekly intervals. The acetyl metabolite has a similarly long half-life, but sulfadoxine is less extensively metabolized than many other sulfonamides.

• 臨床応用

  Sulfadoxine is used only in combination with pyrimethamine.

• 副作用

  Side effects are those common to the group. There have been many reports of Stevens–Johnson syndrome following its use and the combination with pyrimethamine is no longer recommended for the prophylaxis of malaria.

スルファドキシン 上流と下流の製品情報

スルファドキシン 生産企業

Global(436)Suppliers

スルファドキシン スペクトルデータ(¹HNMR)

2447-57-6, スルファドキシン キーワード